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Total Marrow Irradiation With High Dose Melphalan Prior to Autologous Transplant for Multiple Myeloma — BMT-02  

Multiple Myeloma Clinical Trial

Official title:
BMT-02: A Phase I Trial of Total Marrow Irradiation in Addition to High Dose Melphalan Conditioning Prior to Autologous Transplant for Multiple Myeloma Following Initial Induction Therapy

Clinical Trial Summary

In this phase I trial, patients with multiple myeloma will receive standard high dose melphalan with autologous stem cell rescue. In addition the pre-transplant conditioning will include targeted total marrow irradiation (TMI). This conventional 3+3 phase I trial will increase the dose of TMI until the maximum tolerated dose (MTD) is reached. Initial patients enrolled will receive the lowest possible dose of 3Gy. Maximum dose will be 12Gy.

Clinical Trial Description

To establish the maximal tolerated dose of total marrow irradiation which can be added to high dose melphalan conditioning in patients with multiple myeloma undergoing autologous stem cell transplant. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT02043860
Study type Interventional
Source University of Illinois at Chicago
Contact
Status Terminated
Phase Phase 1
Start date January 10, 2014
Completion date November 7, 2016
View Details
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