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Carfilzomib With Bendamustine and Dexamethasone in Multiple Myeloma

Multiple Myeloma Clinical Trial

Official title:
Phase I/II Study of Carfilzomib in Combination With Bendamustine and Dexamethasone in Patients With Newly Diagnosed Multiple Myeloma

Clinical Trial Summary

This study is designed to define dose-limiting toxicity and determine preliminary evidence of efficacy of carfilzomib (CFZ) in combination with bendamustine and dexamethasone for patients with newly diagnosed multiple myeloma (MM).

Clinical Trial Description

Multiple myeloma (MM) is a malignant plasma cell disorder resulting in approximately 11,000 deaths in the United States each year. It is estimated that between 60,000-80,000 people are currently under treatment for refractory or relapsed MM. Prognosis and survival have improved over the last 20 years, but the disease is still universally fatal despite efforts to develop new and more effective chemotherapeutic regimens. Therefore, new regimens need to be developed for patients prior to peripheral blood stem cell transplant and for those unable to tolerate the toxicity of transplant. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT02002598
Study type Interventional
Source Columbia University
Contact
Status Completed
Phase Phase 1/Phase 2
Start date November 2013
Completion date March 1, 2019
View Details
See also
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