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Clinical Trial Summary

This is a treatment guideline for an unrelated umbilical cord blood transplant (UCBT) using a myeloablative preparative regimen for the treatment of hematological diseases, including, but not limited to acute leukemias. The myeloablative preparative regimen will consist of cyclophosphamide (CY), fludarabine (FLU) and fractionated total body irradiation (TBI).


Clinical Trial Description

This is a study to collect routine clinical data from UCBT using unrelated single or double UCB units as an alternative, non-HLA-matched stem cell source for patients with hematological diseases. - data collection from transplant preparative therapy consisting of treatments with chemotherapeutic regimens and total body irradiation. - data collection from umbilical cord blood selection and infusion. - data collection from standard supportive disease and transplant related care. Pre- and post-transplant medication, UCB selection and infusion, supportive care, and follow-up will be according to the current University of Minnesota BMT guidelines. An average of 18 patients are expected to be treated on this protocol per year. ;


Study Design


Related Conditions & MeSH terms

  • Acute Lymphocytic Leukemia (ALL)
  • Acute Myeloid Leukemia (AML)
  • Burkitt Lymphoma
  • Burkitt's Lymphoma
  • Chronic Lymphocytic Leukemia
  • Chronic Myelogenous Leukemia
  • Diffuse Large B Cell Lymphoma
  • Follicular Lymphoma
  • Hematologic Diseases
  • Leukemia
  • Leukemia, Lymphocytic, Chronic, B-Cell
  • Leukemia, Lymphoid
  • Leukemia, Myelogenous, Chronic, BCR-ABL Positive
  • Leukemia, Myeloid
  • Leukemia, Myeloid, Acute
  • Leukemia, Plasma Cell
  • Leukemia, Prolymphocytic
  • Lymphoblastic Lymphoma
  • Lymphoma
  • Lymphoma, B-Cell
  • Lymphoma, B-Cell, Marginal Zone
  • Lymphoma, Follicular
  • Lymphoma, Large B-Cell, Diffuse
  • Lymphoma, Mantle-Cell
  • Lymphoma, Non-Hodgkin
  • Lymphoplasmacytic Lymphoma
  • Mantle-Cell Lymphoma
  • Marginal Zone B-Cell Lymphoma
  • Multiple Myeloma
  • Myelodysplasia
  • Myelodysplastic Syndromes
  • Myelofibrosis
  • Non-Hodgkin Lymphoma
  • Plasma Cell Leukemia
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma
  • Preleukemia
  • Primary Myelofibrosis
  • Prolymphocytic Leukemia
  • Small Lymphocytic Lymphoma
  • Waldenstrom Macroglobulinemia

NCT number NCT01962636
Study type Interventional
Source Masonic Cancer Center, University of Minnesota
Contact Claudio Brunstein, MD
Phone 612-625-3918
Email bruns072@umn.edu
Status Recruiting
Phase N/A
Start date December 2016
Completion date October 2025

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