Multiple Myeloma Clinical Trial
Official title:
A Phase I Study of the Combination of Panobinostat and Carfilzomib in Patients With Relapsed and/or Refractory Multiple Myeloma
The purpose of this study is to find out what effects, good and/or bad, the combination of
panobinostat and carfilzomib have on the patient's cancer. It will determine the side effects
of different dose levels of panobinostat and carfilzomib and determine the best dose and
schedule of the two drugs to recommend for future studies. The study will assess the effects
of the drug on multiple myeloma. In addition, tests to study the way the drugs work will also
be done.
The combination of the 2 drug classes have shown both pre-clinical (studies done in the lab)
and clinical (studies done with people) effects against multiple myeloma. For this reason,
these 2 drugs are being studied in combination to determine the side effects and anti-myeloma
effects of the 2 drugs.
This is a multi-center, open-label, phase I study of panobinostat, carfilzomib in patients with relapsed/refractory multiple myeloma. Based on the preclinical data supporting the use of combined histone de-acetylase (HDAC) and proteasome inhibition, the incidence of single-agent panobinostat and carfilzomib anti-myeloma activity, and clinical data demonstrating safety and efficacy of panobinostat with a different proteasome inhibitor (bortezomib), this study will evaluate the combination of panobinostat and carfilzomib in patients with relapsed/refractory multiple myeloma in a phase I trial. ;
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