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Allogeneic Hematopoietic Stem Cell Transplantation for Multiple Myeloma — Flu-Mel-Vel  

Multiple Myeloma Clinical Trial

Official title:
A Phase II Study of Allogeneic Hematopoietic Stem Cell Transplantation for Multiple Myeloma Using a Conditioning Regimen of Fludarabine, Melphalan, and Bortezomib

Clinical Trial Summary

The hypothesis for this study is that the regimen consisting of fludarabine, melphalan and bortezomib improves the progression free survival and the response rate compared to historical controls of fludarabine and melphalan alone.

Clinical Trial Description

Multiple myeloma is the second most prevalent blood cancer (10%) after non-hodgkin's lymphoma. It represents approximately 1% of all cancers and 2% of all cancer deaths. Although the peak age of onset of multiple myeloma is 70 years of age, recent statistics indicate both increasing incidence and earlier age of onset. The historical control 2-year progression-free survival (PFS) is assumed to be 35%. The proposed therapy of fludarabine, melphalan and bortezomib is expected to improve the PFS by 20%. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT01453101
Study type Interventional
Source Hackensack Meridian Health
Contact
Status Completed
Phase Phase 2
Start date June 9, 2010
Completion date June 11, 2020
View Details
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