Multiple Myeloma Clinical Trial
Official title:
Chemotherapy and Anti-angiogenic Agents- Induced Thrombosis in Cancer.
RATIONALE: Studying samples of blood in the laboratory from patients receiving chemotherapy
may help doctors learn more about the effects of chemotherapy on cells. It may also help
doctors understand how patients respond to treatment.
PURPOSE: This research study is studying biomarkers related to thrombosis in patients with
newly diagnosed multiple myeloma receiving chemotherapy.
| Status | Completed |
| Enrollment | 18 |
| Est. completion date | January 2016 |
| Est. primary completion date | December 2012 |
| Accepts healthy volunteers | No |
| Gender | Both |
| Age group | 18 Years and older |
| Eligibility |
DISEASE CHARACTERISTICS: - Newly diagnosed; relapsed, or refractory multiple myeloma PATIENT CHARACTERISTICS: - Central venous access devices allowed - Recruited by the Division of Hematology/Oncology and the Lineberger Comprehensive Cancer Center at the University of North Carolina - No history of venous thromboembolism - No hospitalization for > 2 days within the past month - Not pregnant - No patient who refuses or is deemed unsuitable for chemotherapy PRIOR CONCURRENT THERAPY: - No surgery within the past month - Bone marrow biopsies, central venous line placement and diagnostic biopsies by surgery or fine-needle aspiration allowed - * No concurrent anticoagulation therapy - Concurrent antiplatelet agents, such as aspirin and/or clopidogrel, allowed |
Time Perspective: Prospective
| Country | Name | City | State |
|---|---|---|---|
| United States | Lineberger Comprehensive Cancer Center at University of North Carolina - Chapel Hill | Chapel Hill | North Carolina |
| Lead Sponsor | Collaborator |
|---|---|
| UNC Lineberger Comprehensive Cancer Center | National Cancer Institute (NCI) |
United States,
| Type | Measure | Description | Time frame | Safety issue |
|---|---|---|---|---|
| Primary | Levels of circulating tissue factor (TF) | 5 years | No | |
| Secondary | Alteration in coagulation parameters | 5 years | No | |
| Secondary | Correlation of TF with markers of coagulation activation and endothelial activation | 5 years | No | |
| Secondary | Incidence of venous thromboembolism | 5 years | No |
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