Multiple Myeloma Clinical Trial
Official title:
Trial of Allogeneic BMT for Hematologic Malignancies Using HLA-matched Related or Unrelated Donors With Fludarabine and IV Busulfan as Pre-transplant Conditioning Followed by Post-transplant Immunosuppression With High-dose Cyclophosphamide
The purpose of this research is to find the most effective and least toxic way to prevent GVHD after BMT.
A person who has cancer of the blood or lymph glands can be treated by bone marrow
transplantation (BMT). BMT has developed over several decades of research on both animal and
human subjects as an effective treatment of various malignant and nonmalignant hematologic
diseases. Many hematologic malignancies can be successfully treated with a combination of
high-dose chemotherapy or chemo-radiotherapy and transplantation of allogeneic bone marrow
or peripheral blood stem cells (alloBMT)
However, a possible side effect of BMT is graft versus host disease (GVHD). GVHD occurs when
cells of the donor's immune system, which are present in the bone marrow, attack the BMT
recipient's normal tissue. Prevention of GVHD is important for the success of the bone
marrow transplant. This research is being done to find the most effective and least toxic
way to prevent GVHD after BMT
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Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
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