Safety Study of Lenalidomide With and Without Dexamethasone in Japanese Subjects With Previously Treated Multiple Myeloma

Multiple Myeloma Clinical Trial

Official title:

A Multicenter, Phase I Study to Determine the Maximum Tolerated Dose, Safety, Pharmacokinetics and Efficacy of Lenalidomide With and Without Dexamethasone in Japanese Subjects With Previously Treated Multiple Myeloma

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT00555100
• Other study ID #: CC-5013-MM-017
• Status: Completed
• Phase: Phase 1
• Start date: July 1, 2007
• Est. completion date: December 1, 2010

Study information

• Verified date: November 2019
• Source: Celgene
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

CC-5013-MM-017 is a Phase I, multicenter study to determine the maximum tolerated dose (MTD), safety profile, pharmacokinetics, and preliminary efficacy of lenalidomide with and without dexamethasone in Japanese subjects with previously treated MM. The study will consist of two cohorts: 1) Monotherapy "Maximum Tolerated Dose (MTD) Determination" Cohort; and 2) "Combination Treatment" Cohort.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 15
• Est. completion date: December 1, 2010
• Est. primary completion date: December 1, 2010
• Accepts healthy volunteers: No
• Gender: All
• Age group: 20 Years and older

Eligibility

Inclusion Criteria:

• Subjects with previously treated multiple myeloma

• Measurable levels of m-protein in serum >= 0.5 g/dL [5g/L]) or urine (>= 0.2 g excreted in a 24-hour collection sample)

• ECOG performance status of 0 - 2

• Willing to follow pregnancy precautions

Exclusion Criteria:

• Patients with acute an myocardial infarction (MI) within the past 6 months, or patients with a history of deep vein thrombosis (DVT) or pulmonary embolism (PE) within the past 3 years

• Patients with tuberculous diseases, herpes simplex keratitis, systemic mycosis or other active infectious diseases

• Patients with non-controlled diabetes, hypertension, digestive ulcer or glaucoma

• Patients with posterior subcapsular cataracts

• Patients with mental illness

• Patients with past histories or complications which make the Investigator or other staff member deem them inappropriate for this study

• Pregnant or lactating females

• Grade 2 or worse neuropathy

• Any of the following laboratory abnormalities:

Absolute neutrophil count (ANC) < 1,000cells/mL Platelet count < 75,000/mL Serum creatinine > 2.5 mg/dL Serum SGOT/AST or SGPT/ALT > 3.0 x upper limit of normal (ULN)

• Prior history of malignancies, other than multiple myeloma, unless the subject has been free of the disease for >= 3 years. - Patients who received radiation therapy within 14 days of the start of study drug

• Patients with scars from a recent viscus operation

• Patients with history of a desquamating (blistering) rash while taking thalidomide

• Patients with prior use of lenalidomide

• Patients with known HIV positivity.

• Patients who used cytotoxic chemotherapeutic agents, immunomodulating agents, or other experimental agents (agents that are not commercially available) intended for the treatment of MM within 28 days of the start of lenalidomide therapy.

• Patients with known history of hypersensitivity to dexamethasone.

Related Conditions & MeSH terms

• Multiple Myeloma
• Neoplasms, Plasma Cell

Intervention

Drug:
• lenalidomide
10mg-25mg PO/day,day1-day21 of each 28day cycle. Number of Cycles:until progression or unacceptable toxicity develops.
• dexamethasone
40mg PO/day, day1-4,9-12,17-20 of each 28day cycle. Number of Cycles:until progression or unacceptable toxicity develops.

Locations

Country	Name	City	State
Japan	Nagoya City University Hospital	Nagoya	Aichi
Japan	National Hospital Organization Nagoya Medical Center	Nagoya	Aichi
Japan	Niigata Cancer Center Hospital	Niigata
Japan	Jichi Medical University Hospital	Shimotsuke	Tochigi
Japan	Keio University Hospital	Tokyo

Sponsors (1)

Lead Sponsor	Collaborator
Celgene

Country where clinical trial is conducted

Japan, 

References & Publications (1)

Iida S, Chou T, Okamoto S, Nagai H, Hatake K, Murakami H, Takagi T, Shimizu K, Lau H, Takeshita K, Takatoku M, Hotta T. Lenalidomide plus dexamethasone treatment in Japanese patients with relapsed/refractory multiple myeloma. Int J Hematol. 2010 Jul;92(1):118-26. doi: 10.1007/s12185-010-0624-7. Epub 2010 Jun 18. Erratum in: Int J Hematol. 2010 Jul;92(1):127-8. — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	DLT		first cycle (28 days)
Secondary	Efficacy (M-protein)		24 weeks