Multiple Myeloma Clinical Trial
Official title:
Phase II Study of Intravenous Ganciclovir Followed by Oral Ganciclovir in the Treatment of Reactivation of CMV Following Bone Marrow Transplant
RATIONALE: Antiviral drugs, such as ganciclovir, act against viruses. Giving ganciclovir by
infusion and then by mouth may be effective treatment for cytomegalovirus that has become
active after donor bone marrow transplant.
PURPOSE: This phase II trial is studying how well giving ganciclovir by infusion and by mouth
works in treating patients with cytomegalovirus after donor bone marrow transplant.
OBJECTIVES:
- To determine the feasibility of using oral ganciclovir (GCV) following induction with
intravenous GCV in the setting of cytomegalovirus (CMV) reactivation after bone marrow
transplantation.
OUTLINE: Blood cultures for cytomegalovirus (CMV) are obtained periodically after the planned
bone marrow transplantation (BMT). Patients showing reactivation of CMV receive induction
ganciclovir (GCV) IV twice a day on days 1-7. Patients then receive maintenance oral GCV
three times a day for 5 weeks in the absence of disease progression or unacceptable toxicity.
Patients undergo blood collection periodically during study for pharmacokinetic studies.
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