Multiple Myeloma Clinical Trial
Official title:
A Phase I/II Study of ATN-224 and Bortezomib in Patients With Multiple Myeloma Relapsed From or Refractory to Bortezomib
The purpose of this study is to describe the safety and effect of ATN-224 in combination with bortezomib (Velcade®) in patients with Multiple Myeloma who are relapsed from or refractory to bortezomib.
Multiple myeloma is a bone marrow based malignancy of plasma cells that is highly treatable
but rarely curable. Angiogenesis, defined as the growth of new blood vessels from
pre-existing vessels, is a requirement for the growth of nearly all tumors. An increase in
bone marrow angiogenesis is present in Multiple Myeloma and correlates with disease
progression. Several new therapies that target angiogenic pathways have shown clinical
efficacy. ATN-224 is a small molecule that has been shown in pre-clinical studies to be
antiangiogenic.
Using one agent to overcome resistance of another agent is a treatment regimen used in
oncology. A preclinical study with the combination of ATN-224 and bortezomib shows that the
combination is more effective than either single agent in a bortezomib resistant cell line.
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Allocation: Non-Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
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