Multiple Myeloma Clinical Trial
Official title:
Phase I/II Study of Allogeneic Stem Cell Transplantation for Patients With Hematologic Malignancy, Using MHC Identical or Near Identical Donors and Sub-Myeloablative Conditioning With CAMPATH 1H (DIMSUM)
1. To assess the treatment related mortality of allogeneic stem cell transplantation with
non-myeloablative therapy incorporating the lymphodepleting MAb CAMPATH-1H, in patients
with hematological diseases and renal cell carcinoma not eligible for conventional
(myeloablative) therapy.
2. To assess the time to engraftment and incidence of graft failure in patients receiving
this transplant regimen.
3. To assess the safety, pharmacokinetics and immunologic activity of CAMPATH-1H when used
as part of a subablative conditioning regimen.
This is a two arm study in which outcomes will be assessed independently in recipients of HLA
matched sibling transplants and recipients of unrelated or mismatched family donor
transplants, although both groups will receive identical treatments.
The following will be given to the patient after admission:
Day - 6: Total body irradiation
Day - 5 to - 2: Fludarabine and Campath 1H
Day - 1: Day of rest
Day 0: Stem cell transplant (infusion)
;
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