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Proteomic and Metabolomic Lacrimal Fingerprint in Diverse Pathologies of the Ocular Surface — EML-MSO  

Dry Eye Syndrome Clinical Trial

Official title:
Proteomic and Metabolomic Lacrimal Fingerprint in Diverse Pathologies of the Ocular Surface

Clinical Trial Summary

This study aims to obtain the lacrimal fingerprint for frequent pathologies of the ocular surface and establish a normative base for each of them.

Clinical Trial Description

This is an exploratory study. The investigators aim to: - Test and perfect a tear sample analysis technique by mass spectrometry with samples collected by Schirmer strips; - Obtain the lacrimal fingerprint for various pathologies of the ocular surface, notably different forms of dry eye syndrome, infectious keratitis/conjunctivitis, mucous membrane pemphigoid and allergic conjunctivitis, and establish a normative base for each of them. During regular clinics at the cornea service of the ophthalmology department of the CHUM (Centre Hospitalier de l'Université de Montréal), the investigators aim to recruit a few hundred patients with various pathologies of the ocular surface, notably different forms of dry eye syndrome, infectious keratitis/conjunctivitis, mucous membrane pemphigoid and allergic conjunctivitis, and collect a sample of their tears via Schirmer strip. A case report form will be completed for each patient, noting known ocular diagnoses and active topical ophthalmic medication. Schirmer strips will be sent in sterile tubes to UQAM (Université du Québec à Montréal)'s department of chemistry for analysis by mass spectrometry. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04198740
Study type Observational
Source Centre hospitalier de l'Université de Montréal (CHUM)
Contact Marie-Claude Robert, MD, M.Sc
Phone 514-890-8278
Email marie-claude.robert.2@umontreal.ca
Status Recruiting
Phase
Start date February 1, 2020
Completion date January 2035
View Details
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