Mucopolysaccharidoses Clinical Trial
Official title:
Assessment of Factors That Affected Respiratory Parameters in Mucopolysaccharidoses Patients
Respiratory system affects in mucopolysaccharidosis (MPS) disease. Respiratory system symptoms are seen in almost every MPS patients and respiratory failure is one of the most common causes of death in this population. The aim of the study was to evaluate respiratory muscle strength and endurance, cough effectiveness and functional capacity in MPS patients and to defined the factors that affected the respiratory problem in this.
This study was participated MPS patients. Patients' pulmonary function test, functional
capacity, respiratory muscle strength and endurance, peak cough flow was assessed and
recorded.
Pulmonary function test was assessed with spirometry, functional capacity was evaluated with
3-minute step test and six minute walk test (MWT). Respiratory muscle strength was evaluated
mouth pressure measurement (MIP- maximal inspiratory pressure and MEP- maximal expiratory
pressure) and Sniff nasal inspiratory pressure (SNIP). Respiratory muscle endurance was
assessed Powerbreathe. And cough effectiveness was evaluated peak cough flow.
;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Terminated |
NCT01675674 -
Study to Detect Unrecognized Mucopolysaccharidosis in Children Visiting Rheumatology, Hand or Skeletal Dysplasia Clinics
|
N/A | |
| Recruiting |
NCT05063435 -
Cardiovascular Structure and Function in the Mucopolysaccharidoses
|
||
| Active, not recruiting |
NCT03632213 -
Evaluation of Losartan on Cardiovascular Disease in Patients With Mucopolysaccharidoses IV A and VI
|
Phase 2 | |
| Recruiting |
NCT02583152 -
New Imaging Technology to Assess Effect of Enzyme Replacment Therapy on Eye Disease Progession in Mucopolysacchardiosis
|
N/A | |
| Completed |
NCT04112602 -
Respiratory Cathepsins, Proteases Inhibitors and Glycosaminoglycans (GAG) in Mucopolysaccharidosis
|
||
| Recruiting |
NCT05354219 -
Validation and Reliability of Iris Cameras in Mucopolysaccharidoses
|
||
| Completed |
NCT01586871 -
Carotid Structure and Function in MPS Syndromes: A Multicenter Study of the Lysosomal Disease Network
|
||
| Active, not recruiting |
NCT02699190 -
LeukoSEQ: Whole Genome Sequencing as a First-Line Diagnostic Tool for Leukodystrophies
|
||
| Not yet recruiting |
NCT03017677 -
A Cross-specialty Collaboration Platform for Mucopolysaccharidosis Confirmative Diagnosis
|
N/A | |
| Recruiting |
NCT03047369 -
The Myelin Disorders Biorepository Project
|
||
| Not yet recruiting |
NCT04637646 -
Evaluation of Cardiac Affections in Patients With Mucopolysaccharidosis (MPS) in Assuit University Children Hospital (AUCH)
|
||
| Completed |
NCT01521429 -
Longitudinal Study of Bone Disease in Children With Mucopolysaccharidoses (MPS) I, II, and VI
|