MRSA Clinical Trial
— SUSTAINOfficial title:
Stop Community MRSA Colonization Among Patients (SUSTAIN)
Verified date | March 2018 |
Source | Johns Hopkins University |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
This research is being done to learn more about an approach to remove Methicillin resistant
Staphylococcus aureus (MRSA) in patients who are carriers of the bacteria in outpatient
settings and among their household members and sexual partners.
MRSA is a type of bacteria or germ that can cause bad infections of the skin that can make
people very sick. The bacteria have been seen in a high number of persons in the Baltimore
area and in hospitals throughout the country. MRSA can be spread from person to person,
particularly in homes and among family members and sexual partners.
There are three things the investigators hope to learn from this research study:
First, the investigators want to find a way to prevent MRSA infections in outpatient
settings. By asking questions, the investigators want to look at the things that may increase
the risk of having this type of bacteria in you and your family members.
Second, the investigators have soaps and oral rinses (Chlorhexidine) and medications
(antibiotics; Mupirocin ointment) that have been shown to be effective at removing MRSA. The
investigators want to determine if these antibiotics and soaps are best used for everyone in
the household or only the individual with known MRSA.
Third, as the investigators, we want to learn more about the bacteria by looking at it on the
inside. The investigators will do laboratory tests on samples we collect, to learn how MRSA
bacteria grow, reproduce and how it develops to behave differently than other types of MRSA
bacteria.
Status | Completed |
Enrollment | 77 |
Est. completion date | March 2017 |
Est. primary completion date | March 2017 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 6 Months and older |
Eligibility |
Inclusion Criteria: - Individuals, 21 years of age and older, of all racial and ethnic groups, receiving care within the Johns Hopkins University AIDS Service who have a prior history of MRSA colonization are eligible to participate as the index HIV positive subject - have at least two members in the household and/or a sexual partner - subjects must be willing to be randomized to either arm of the study, including randomization to household and/or sexual partner evaluation that includes home visits - Sexual partners and/or household members will also be required to provide informed consent - Subjects and their contacts must have no documented or reported allergies to any agent used in the standardized decolonization regimen - Parental assent will be required for household members less than 7 years of age Exclusion Criteria: - individuals who live alone and have no active sexual partners - allergy to any component of decolonization protocol - individuals who are unable to provide written informed consent |
Country | Name | City | State |
---|---|---|---|
United States | Johns Hopkins Hospital | Baltimore | Maryland |
Lead Sponsor | Collaborator |
---|---|
Johns Hopkins University | Robert Wood Johnson Foundation |
United States,
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* Note: There are 23 references in all — Click here to view all references
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Number of Participants With Recurrent Methicillin-resistant Staphylococcus Aureus (MRSA) Colonization | Participants were decolonized with a standard Methicillin-resistant Staphylococcus aureus (MRSA) decolonization protocol and monitored for 6 months. This is the number of participants who screened positive for Methicillin-resistant Staphylococcus aureus (MRSA) 6 months after being decolonized (i.e., recurrent infection) | 6 months |
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