MRSA-Colonization Clinical Trial
Official title:
The Value of Whole Body Washing With Chlorhexidine for the Eradication of MRSA – a Randomized, Placebo-Controlled, Double-Blinded Clinical Trial
The purpose of this study is to determine whether whole body washing with chlorhexidine in combination with mupirocine nasal ointment is effective in the eradication of meticillin-resistant Staphylococcus aureus (MRSA).
The number and rate of infections due to meticillin-resistant Staphylococcus aureus (MRSA)is
increasing world wide. Patients who are colonized with MRSA are the main source for further
distribution. In addition colonization with MRSA is a precondition for infection.
Whole body washing with antiseptic solutions as part of eradication strategies for MRSA has
been widely used. However, there is insufficient evidence to support use of topical
antimicrobial therapy for eradicating of MRSA because treatment with antiseptic solution has
never been compared to placebo.
Comparison: The efficacy of whole body washing in the control of MRSA was studied in a
randomized, placebo-controlled, double-blinded clinical trial. The study treatment consisted
of five days of whole body washing either with 4% chlorhexidine solution (verum) or with
placebo. All patients received mupirocin nasal ointment and chlorhexidine mouth rinse. The
outcome was evaluated 3, 4, 5, 9 and 30 days after treatment by swabs taken from several
body site.
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Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double-Blind, Primary Purpose: Treatment