Clinical Trial Details
— Status: Completed
Administrative data
| NCT number |
NCT04957043 |
| Other study ID # |
M2018017 |
| Secondary ID |
|
| Status |
Completed |
| Phase |
|
| First received |
|
| Last updated |
|
| Start date |
March 1, 2018 |
| Est. completion date |
June 1, 2019 |
Study information
| Verified date |
June 2021 |
| Source |
Peking University Third Hospital |
| Contact |
n/a |
| Is FDA regulated |
No |
| Health authority |
|
| Study type |
Observational
|
Clinical Trial Summary
3 d scan sequence can realize continuous thin layer scanning, the thinnest layer thickness of
0.5 mm, to reduce the effects of partial volume effect and improve the spatial resolution
image, the other 3 d sequence can according to need to multiplanar reconstruction based on
the original image, the image of the watch is no longer limited to a fixed plane, and can
avoid repeated scanning, reducing overall inspection time. Initially, 3D MRI uses gradient
echo sequences (3D-GRE). Although the scan time of 3D-GRE is acceptable and has a high
spatial resolution, the contrast between tissues is poor. In recent years, is voxel 3D fast
spin-echo sequence (3D-FSE) has become an alternative 3D scanning sequence. Compared with the
3D-GRE sequence, 3D-FSE has better-intertissued contrast. However, there are still some
problems in the application of 3D sequence in clinical practice. On the one hand, although 3D
sequence reduces the overall scanning time, it increases the single scanning time, so it is
easy to produce motion artifacts. On the other hand, although many studies have demonstrated
the diagnostic efficacy of 3D sequences in the diagnosis of common intraarticular structural
injuries, especially in the diagnosis of knee cartilage injuries, the diagnostic value of 3D
sequences is comparable to that of conventional 2D-FSE sequences, but the evidence on whether
3D sequences can replace 2D sequences is still insufficient.
Recently, a new fast signal acquisition technology -- Compressed Sensing (Compressed Sensing)
technology has been gradually applied to many kinds of MRI sequences, and its application in
3D sequences can greatly shorten the single scan time. In this study, Modulated Flip Angle
Technique in Refocused Imaging with Extended Echo was applied by United Imaging Co., Ltd.
(Compressed Sensing) Train, 3D-Matrix), which is a fast self-selected echo sequence based on
variable turn Angle technology, and its single scan time can be shortened to 5 minutes. 3 d
sequence to more systematic evaluation on sports injury of knee joint application value, the
investigators will study from within the bony structure of knee joint injury, joint structure
damage and injury of the surrounding support structure aspects to discuss the diagnosis
effect, and with arthroscopy for the gold standard to evaluate the accuracy of the 3 d
structure within the sequence in the diagnosis of knee joint injury.
Description:
Magnetic resonance imaging (MRI) is the most important non-invasive examination method for
the diagnosis of knee joint sports injury. 2D-FSE sequence is usually used for axial,
sagittal and coronal scanning in MR examination of the knee joint. The sequence has good
tissue contrast and spatial resolution. However, there are still some problems with 2D-FSE
sequences. For example, the scanning layer thickness is usually up to 3-5mm, and there is a
certain layer spacing, resulting in partial volume effect. In addition, in order to obtain
images with different azimuths, the same sequence needs to be scanned for many times, which
increases the overall inspection time.
3 d scan sequence can realize continuous thin layer scanning, the most thin layer thickness
of 0.5 mm , so as to reduce the effects of partial volume effect and improve the spatial
resolution image, the other 3 d sequence can be on the basis of the original image according
to need multiplanar reconstruction, make the observation of the image is no longer limited to
the fixed plane, and can avoid repeated scanning, reducing overall inspection time.
Initially, 3D MRI uses gradient echo sequences (3D-GRE). Although the scan time of 3D-GRE is
acceptable and has high spatial resolution, the contrast between tissues is poor. In recent
years, the isosvoxel 3D fast spin echo sequence (3D-FSE) has become an alternative 3D
scanning sequence. Compared with 3D-GRE sequence, 3D-FSE has better intertissue contrast .
However, there are still some problems in the application of 3D sequences in clinical
practice. On the one hand, although 3D sequences reduce the overall scanning time, the single
scanning time increases. At present, the scanning time in most studies is generally 6-10
minutes , so motion artifacts are easily generated. On the other hand, although many studies
have proved the diagnostic efficacy of 3D sequence in the diagnosis of common intraarticular
structural injuries , especially the diagnostic value of 3D sequence in the diagnosis of knee
cartilage injuries is equivalent to that of conventional 2D-FSE sequence, there is
insufficient evidence on whether 3D sequence can replace 2D sequence .
Recently, a new fast signal acquisition technology -- Compressed Sensing (Compressed Sensing)
technology has been gradually applied to a variety of MRI sequences , and its application in
3D sequences can greatly shorten the single scan time. In this study, Modulated Flip Angle
Technique in Refocused Imaging with Extended Echo was applied by United Imaging Co., Ltd.
(Compressed Sensing) Train, 3D-Matrix), which is a fast self-selected echo sequence based on
variable turn Angle technology, and its single scan time can be shortened to 5 minutes. 3 d
sequence in order to more systematic evaluation on sports injury of knee joint application
value, the investigators will study from within the bony structure of knee joint injury,
joint structure damage and injury of the surrounding support structure aspects to discuss the
diagnosis effect, and with arthroscopy for gold standard to evaluate the accuracy of the 3 d
structure within the sequence in the diagnosis of knee joint injury.
