MRI Clinical Trial
— CS-QSMOfficial title:
Évaluation de l'Impact du Compressed Sensing Sur le Signal QSM
Patients who have agreed to participate in the study will complete the MRI protocol as part of routine care, to which a maximum of four additional 25-minute sequences will be added. MRI of routine care includes at least the following sequences: - 3D T1 TFE (2 minutes) - T2 TSE (2 minutes) - 3D FLAIR (3 minutes) The sequences added by the research lasting 25 minutes are: - SWI QSM 1.0iso 8 echoes (10 minutes) - SWI QSM 1.0iso 8 echoes CS 6 (7 minutes) - SWI QSM 1.0iso 8 echoes CS 9 (5 minutes) - SWI QSM 1.0iso 8 echoes CS 12 (3 minutes)
| Status | Recruiting |
| Enrollment | 60 |
| Est. completion date | April 27, 2025 |
| Est. primary completion date | June 27, 2024 |
| Accepts healthy volunteers | No |
| Gender | All |
| Age group | 18 Years and older |
| Eligibility | Inclusion Criteria: For patients with MS: - Patient over 18 years old - Presenting MS defined according to McDonald's revised criteria for spatial and temporal clinical or radiological dissemination [16], - Should benefit as part of the care of an MRI examination with or without injection of gadolinium - Express consent to participate in the study - Affiliate or beneficiary of a social security scheme For patients with an indication to undergo a brain MRI and at low risk of inflammatory CNS disease: - Patient over 18 years old - Should benefit as part of the care of an MRI examination with or without injection of gadolinium - Express consent to participate in the study - Affiliate or beneficiary of a social security scheme Exclusion Criteria: - For patients with MS: - Patient benefiting from a legal protection measure - Pregnant or breastfeeding woman For patients with an indication to undergo a brain MRI and at low risk of inflammatory CNS disease: - Patient benefiting from a legal protection measure - Pregnant or breastfeeding woman - Patient with inflammatory and / or demyelinating pathology of the CNS Secondary exclusion criteria : - Motion artefact not allowing interpretation of images - Patient who did not perform one of the following sequences: 3D T1 TFE, 3D FLAIR (for MS patients), SWI QSM 1.0iso 8 echoes. Secondarily excluded patients will be replaced. |
| Country | Name | City | State |
|---|---|---|---|
| France | Hhopital fondation adolphe de rothschild | Paris |
| Lead Sponsor | Collaborator |
|---|---|
| Fondation Ophtalmologique Adolphe de Rothschild |
France,
| Type | Measure | Description | Time frame | Safety issue |
|---|---|---|---|---|
| Primary | concordance of QSM signal with and without compressed-sensing in white matter | concordance of QSM signal with and without compressed-sensing in white matter | 1 DAY |
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