Ultrasound Findings of Finger, Wrist and Knee Joints in Mucopolysaccharidosis

MPS I Clinical Trial

Official title:

Ultrasound Findings of Finger, Wrist and Knee Joints in Mucopolysaccharidosis

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT02067650
• Other study ID #: MPSUS
• Status: Completed
• Phase: N/A
• First received: August 13, 2013
• Last updated: January 23, 2018
• Start date: September 2013
• Est. completion date: December 2016

Study information

• Verified date: January 2018
• Source: Children's Hospital of Eastern Ontario
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

Hardly any imaging studies specifically addressing the articular and periarticular structures in MPS patients are available at this point. The investigators propose to do for the first time a pilot study using musculoskeletal ultrasound in patients with various types of MPS.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 18
• Est. completion date: December 2016
• Est. primary completion date: March 2016
• Accepts healthy volunteers: No
• Gender: All
• Age group: 2 Years to 99 Years

Eligibility

Inclusion Criteria

• Diagnosis of Mucopolysaccharidosis

• Ability to collaborate with the ultrasound assessment

• Written informed consent from parents and patients over 14 years of age, assent from children 7 to 14 years

Exclusion Criteria

• Inability to collaborate with the ultrasound assessment

• Acute trauma to a joint that will be assessed in the 3 months preceding the study

• Coexistence of other pathology that is known to affect the respective joints

Related Conditions & MeSH terms

• MPS I
• MPS IV
• Mucopolysaccharidoses

Locations

Country	Name	City	State
Canada	Children's Hospital of Eastern Ontario	Ottawa	Ontario

Sponsors (1)

Lead Sponsor	Collaborator
Children's Hospital of Eastern Ontario

Country where clinical trial is conducted

Canada, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Power Doppler	The primary objective is to determine whether patients with various types of MPS and at various stages of the disease exhibit abnormalities of the finger, wrist and knee joints as assessed by grey scale and Power Doppler ultrasonography.	one time exam
Secondary	Ultrasound scanning technique	To determine the optimal ultrasound scanning technique for MPS patients given the potentially advanced joint contractures	one time scan
Secondary	Findings of synovitis or tenosynovitis	To determine whether there are ultrasound findings indicative of synovitis or tenosynovitis	one time scan
Secondary	Differences between MPS I and IV	To determine whether differences exist between MPS I and MPS IV	one time scan
Secondary	Differences between ERT and BMT	To determine whether differences exist between patients with or without Enzyme Replacement Therapy (ERT) or Bone Marrow Transplants	one time scan
Secondary	Differences between severe and attenuated phenotypes	To determine whether differences exist between severe and attenuated phenotypes	one time scan