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RNF213 Variants and Collateral Vessels in Moyamoya Disease

Moyamoya Disease Clinical Trial

Official title:
RNF213 Variants and Collateral Vessels in Moyamoya Disease

Clinical Trial Summary

The purpose of this study is to detect the association between RNF213 variants and collateral vessels in patients with moyamoya disease.

Clinical Trial Description

Moyamoya disease (MMD) is a chronic cerebrovascular disorder characterized by the presence of occlusion which occurs at the internal carotid arteries and their main branches during the development of a basal collateral network. The ring finger 213 (RNF213) was identified as a strong susceptibility gene in patients with MMD in East Asia. The role of RNF213 variants in pathogenesis of MMD is still unclear. Specific "moyamoya vessels" correlate with the onset of stroke. The purpose of this study is to investigate the relationship between RNF213 variants and collateral vessels in patients with moyamoya disease, and provide potential pathogenesis of moyamoya disease. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04906564
Study type Observational
Source Beijing Tiantan Hospital
Contact
Status Completed
Phase
Start date January 1, 2019
Completion date June 30, 2021
View Details
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