The Role of m6A RNA Modification in Moyamoya Disease

Status Recruiting

Clinical Trial Summary

The purpose of this study is to detect the change of m6A RNA modification from peripheral blood of patients with moyamoya disease, and to assess the relationship between clinical characteristics.

Clinical Trial Description

Moyamoya disease (MMD) is a rare cerebrovascular disorder characterized by occlusion of bilateral internal carotid and intracerebral arteries with the compensatory growth of fragile small vessels. The etiology of disease is still unclear. The pathology is associated with blood vessels, characterizing the molecular changes of blood in patients with MMD may yield insights into the disease. N6-methyladenosine (m6A) is identified to be the most common and abundant RNA molecular modification in eukaryotes, and involves in a variety of metabolic processes of RNA, such as RNA transcription, shearing, nuclear transport, and translation ability. The propose of this study is to investigate the change of m6A RNA modification in patients blood with moyamoya disease and its influence on clinical indicators, aiming to provide potential pathogenesis of moyamoya disease. ;

Study Design

Related Conditions & MeSH terms

Moyamoya Disease

Clinical Trial Details

NCT number	NCT04696094
Study type	Observational
Source	Beijing Tiantan Hospital
Contact	Qian Zhang, MD
Phone	008613611075005
Email	zhangqianchina@yahoo.com
Status	Recruiting
Phase
Start date	January 1, 2021
Completion date	December 31, 2022

View Details

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