Magnetic Resonance Imaging Clinical Trial
Official title:
Multimodal Magnetic Resonance Imaging Predicting Outcome After Surgical Revascularization in Patients With Moyamoya Disease
Moyamoya disease (MMD) is a nonatherosclerotic cerebrovascular abnormality, characterized by a progressive stenosis or occlusion of the intracranial internal carotid arteries (ICAs) and their proximal branches, with subsequent formation of collateral vessels ("puff of smoke"). In some cases, the posterior circulation can also be involved. MMD has been discovered around the world, but Asians carry the most possibility to develop this disease. Current treatment designed to prevent strokes by improving blood flow to the affected cerebral hemisphere including medical therapy and surgery. In particular, surgery included two general methods: direct and indirect revascularization. Compared with direct bypass, indirect procedures are more technically accessible and may reduce the possibility of complications, such as hyperperfusion. In addition, magnetic resonance imaging (MRI) with derived parameters have shown great potential in evaluating perfusion in patients, and could possibly predict surgical outcome. However, there is still lack of evidence of the predictive value of MRI in evaluating clinical and angiography improvement in patients with MMD.
Imaging protocols:
3D TOF 3SLAB; SWAN; 3D ASL 2.0s; T1; T2; T2 Flair; DWI; tASL 2.0s; DCE; APT-CEST
Imaging evaluation:
1. Transfer contrast volume value measured by DCE;
2. ASL shows CBF in associated regions;
3. Stoke area measured by DWI and Flair;
4. PH values reflected by APT-CEST.
Treatment:
Surgery-indirect revascularization
Follow-up:
Baseline (MRI+DSA); 3-months follow-up (MRI); 6-months follow-up (MRI+DSA)
;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Not yet recruiting |
NCT03726788 -
Intra Articular Injection of Botulinum Toxin Versus Corticoids in Gonarthrosis
|
Phase 2 | |
| Active, not recruiting |
NCT01956409 -
Proton MR Spectroscopy and 18F-Fluorocholine PET for Breast Cancer Diagnosis
|
Phase 4 | |
| Completed |
NCT01660841 -
Safety and Efficacy of Gadobutrol 1.0 Molar in Japanese Subjects for CNS Imaging
|
Phase 3 | |
| Recruiting |
NCT03635619 -
The Application of 3T MRI in Esophageal Cancer
|
||
| Recruiting |
NCT03658343 -
T2* MRI Analysis for Sarcoma
|
N/A | |
| Recruiting |
NCT04555642 -
Early Diagnosis of Therapy-associated Cardiotoxicity Basing on Multi-tracer Multimodality PET/MRI
|
||
| Active, not recruiting |
NCT03441867 -
Neuroimaging Biomarker for Seizures
|
N/A | |
| Recruiting |
NCT04850001 -
Cognitive Decline in Asymptomatic Intracranial Stenosis Patients: A 1-Year Follow-Up Study
|
||
| Not yet recruiting |
NCT05816213 -
Point-of-care Low-field MRI in Acute Stroke
|
||
| Active, not recruiting |
NCT05498623 -
MR Fingerprinting for Diagnostic of Prostate Cancer
|
||
| Recruiting |
NCT04257747 -
Qualitative and Quantitative Evaluation of Vascular Flows of Radial, Ulnar and Interdigital Arterial Trees Under Normal and Pathological Conditions by 3 Tesla MRI
|
N/A | |
| Recruiting |
NCT04996615 -
Artificial Intelligence Analysis for Magnetic Resonance Imaging in Screening Breast Cancer in High-risk Women
|
||
| Recruiting |
NCT05889117 -
Brain Stimulation for Concussion
|
N/A | |
| Completed |
NCT02540967 -
Drug Use Investigation of Gadovist.
|
||
| Completed |
NCT05103189 -
4D-flow Cardiac MRI to Assess Pulmonary Arterial Pressure in Pulmonary Hypertension
|
N/A | |
| Completed |
NCT02567318 -
Is the Volume of the Caudate Nuclei Associated With Area of Secondary Hyperalgesia?
|
N/A | |
| Recruiting |
NCT02834585 -
Magnetic Resonance Imaging or Ultrasound in Soft Tissue Tumors (MUSTT)
|
N/A | |
| Active, not recruiting |
NCT02446665 -
Disease Status in Primary Sclerosing Cholangitis by Elastography
|
N/A | |
| Completed |
NCT01721785 -
Diagnostic Value of Novel MR Imaging Techniques for the Primary Staging and Restaging of Rectal Cancer
|
N/A | |
| Completed |
NCT01223404 -
Nicotinic Modulation of the Default Network
|
N/A |