Relationship Between Endothelial Progenitor Cells & Revascularization

Status Recruiting

Clinical Trial Summary

Moyamoya disease is a chronic cerebrovascular disease，The typical pathological manifestations are the stenosis or occlusion of the distal internal carotid artery and/or middle cerebral artery, and the proximal anterior cerebral artery. Meanwhile, the abnormal vascular net, which is the smokey vessel, occurs at the bottom of the brain. Currently the pathogenesis of this disease is unknown. Limited studies have reported the expression of endothelial progenitor cells (EPCs) in moyamoya disease, but the results were inconsistent. Some investigators believe that the number of EPCs in peripheral blood of patients with moyamoya disease is increased, while others believe that the number of EPCs in peripheral blood of moyamoya patients is reduced. Therefore, the investigators need to find a more accurate detection method to confirm the growth of EPC in patients with moyamoya disease. At the same time, whether there is endothelial injury in patients with smoke disease, and the expression of endothelial cells (CEC) in patients with smoke disease, there is no research on this aspect at home and abroad.

Clinical Trial Description

Objective: Detect the expression of endothelial progenitor cells and endothelial cells from peripheral blood of patients with moyamoya disease, and to assess the relationship between clinical characteristics.

Design: A single center study, and planned to enroll 120 patients. The present study was to detect the quantities of EPC from peripheral blood in Moyamoya disease by flow cytometry, and to identify the relationship of endothelial progeIlitor cells and effect of the revascularization on Moyamoya disease. The present study also use cerebral ischemia animal model foe intervention experiment, to explore whether EPC can promote vascular remodeling effect of ischemic cerebrovascular disease, and to provide new thought for the treatment of chronic cerebrovascular disorder. ;

Study Design

Related Conditions & MeSH terms

Moyamoya Disease

Clinical Trial Details

NCT number	NCT03613701
Study type	Observational [Patient Registry]
Source	Affiliated Hospital to Academy of Military Medical Sciences
Contact	Lian Duan, Chief
Phone	0086-10-66947156
Email	keyan307@163.com
Status	Recruiting
Phase
Start date	September 1, 2017
Completion date	December 1, 2020

View Details

See also
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Recruiting	`NCT02074111` - Moyamoya Disease Biomarkers in Patients With Intracranial Atherosclerotic Stroke	N/A
Recruiting	`NCT04696094` - The Role of m6A RNA Modification in Moyamoya Disease
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Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.

Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.

Relationship Between Endothelial Progenitor Cells and Revascularization Effect of Moyamoya Disease — REPCREMMD

Clinical Trial Summary

Clinical Trial Description

Study Design

Related Conditions & MeSH terms