Moyamoya Disease Clinical Trial
Official title:
Efficacy and Safety of rTMS for Cognitive Rehabilitation in Moyamoya Disease
The purpose of this study is to evaluate the safety and effectiveness of transcranial magnetic stimulation (TMS) therapy in moyamoya patients who received surgical revascularization.
Primary Outcome Measures:
TMS stimulation applied to the left DLPFC has a quantifiable effect on cognition [ Time
Frame: Neuropsychological Assessments: Baseline（7days after STA-MCA bypass surgery）; 2 months
after TMS treatment Changes in one or more assessed cognitive domains at baseline will be
measured by comparing the scores for the different neuropsychological tests.
Secondary Outcome Measures:
Change in structural grey and white matter in the brain at baseline compared to after TMS
stimulation [ Time Frame: MRI: Baseline and two months after TMS stimulation ] MRI analysis
will measure any changes in cortical thickness (mm) or other structural changes in the brain
after TMS or Sham-TMS stimulation
Change in executive functioning measured as resting-state functional MRI (fMRI) sequence [
Time Frame: MRI: Baseline and two months after TMS stimulation ] fMRI analysis will measure
any changes in amplitude of low frequency fluctuation(ALFF) and other functional changes
after TMS stimulation compared to baseline.
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