Moyamoya Disease Clinical Trial
Official title:
Neurocognitive and Radiological Assessments in Adult Patients With Moyamoya Disease Undergoing Surgical Revascularization
Adult patients with moyamoya disease (MMD) are reported to suffer from considerable
impairment of executive function/attention. Although reduced cerebrovascular reserve (CVR) in
frontal areas has been detected by perfusion MRI and then confirmed to be associated with
executive dysfunction in adult MMD, the structural and functional changes is still unclear
with progression of executive dysfunction. Furthermore, it is very important to study the
association between the neurocognitive and radiological improvement after surgical
revascularization, so as to help detecting cerebral regions which are involved in executive
deterioration or improvement after surgery. Then the investigators can determine whether
these regions can be used as indicators to decide rational therapeutic schedule and timing of
adult MMD with executive dysfunction.
Thus the aim of this study is to primarily find out the neuropsychological and radiological
correlates in adult MMD, and then to quantitatively evaluate the effectiveness of surgical
revascularization in prevention of executive dysfunction in adult MMD.
Previous studies of adult moyamoya disease (MMD) have revealed that vascular cognitive
impairment (VCI) is the consequence of ischemic damage to dynamic factors such as cerebral
hypoperfusion, rather than to cerebral gray matter. However, it is still unclear which
regions are affected by MMD and how these regions respond to the progressive cognitive
decline. In other way, the investigators need to detect spatial patterns in the brain
activity of MMD in order to understand its pathophysiological nature.
Surgical revascularization has been accepted as the only effective form of treatment in
preventing future ischemic episodes. However, its effectiveness in cognitive protection is
still unknown. Thus, the investigators determine to quantitatively evaluate cognitive and
radiological outcomes in adult MMD postoperatively and during follow-ups.
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