Movement Disorder Clinical Trial
Official title:
Cerebral Activity Related to Primary Motor Stereotypies in Children: An EEG Study
Background:
- Motor stereotypies are a movement disorder characterized by involuntary, repetitive, and
rhythmic movements. These movements have a predictable pattern and seem purposeful, but
they serve no obvious function, tend to be prolonged, and can be suppressed. Common
examples of motor stereotypies include hand waving, head nodding, and body rocking.
- Researchers are interested in learning more about motor stereotypies. Many children with
autism and other developmental disorders tend to exhibit these behaviors, but normal
healthy children and even some adults have demonstrated motor stereotypies under certain
conditions (including boredom and stress). More research is needed to determine the
internal causes of and potential successful treatments for these behaviors.
Objectives:
- To use electroencephalography (EEG) to study cerebral activity related to stereotypies in
children.
Eligibility:
- Children between 7 and 18 years of age who demonstrate stereotypy movements on a consistent
basis (at least 10 times a day for at least 4 months).
Design:
- The study will require two visits to the National Institutes of Health Clinical Center.
- First visit: Outpatient screening visit to determine the child s eligibility for the
study, including questionnaires for parents/guardians and a medical assessment of the
stereotypies.
- Second visit: Participating children will spend 1 day in a room at the NIH Clinical
Center Pediatric Day Hospital. During the visit, participants will wear a portable EEG
unit to measure brain activity. For the first hour of the visit, researchers will
perform movement tests to study the brain activity related to normal movements. For the
rest of the day, participants may play games, watch television or movies, read, or nap,
while continuing to wear the EEG to monitor brain activity related to the stereotypic
movements.
- Participants will receive a small amount of compensation for their time and
participation.
Objective
Motor stereotypy is a common movement disorder observed in children and adolescents but whose
pathophysiology is unknown. Therefore, our overall objective is to study cerebral activity
related to stereotypies. First, we want to define whether motor stereotypies are preceded by
a cortical potential, as it is observed before voluntary movements. We hypothesize that no
pre-movement potentials will precede the stereotypies. However, if a pre-movement potential
is observed, our secondary objective is to compare this potential to cortical potentials that
precede voluntary movements. We also aim to study cortical potentials preceding voluntary
movements in healthy children and to compare them with the potentials observed in children
with stereotypies.
Study population
12 children presenting with primary motor stereotypies and 12 healthy children.
Design
Using 19 scalp electrodes, we will record the patients electroencephalographic (EEG) activity
for up to 8 hours during one day. The electromyographic (EMG) activity of the muscles
involved in the stereotypies will be recorded with surface EMG electrodes. Healthy children
will undergo an EEG for 2 hours. During this EEG recording, they will be asked to perform
arms movements.
Outcome measures
Primary outcomes: latency and amplitude of both evoked and induced activity (cortical
potentials) related to motor stereotypies will be measured.
Secondary outcomes: latency and amplitude of evoked and induced activity related to voluntary
movements will be measured.
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