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Motor Symptoms clinical trials

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NCT ID: NCT05562414 Recruiting - Clinical trials for High-Intensity Interval Training

Transient and Immediate Motor Effects of Exercise in Progressive Multiple Sclerosis

TIME
Start date: October 1, 2022
Phase: N/A
Study type: Interventional

Endurance training is a cornerstone of rehabilitation in Multiple Sclerosis (MS) due to its beneficial effects on multiple MS-related symptoms, such as health-related quality of life, aerobic capacity (VO2peak), functional mobility, gait, depressive symptoms, and fatigue. Persons with progressive phenotypes of MS, namely primary progressive MS (PPMS) and secondary progressive (SPMS), represent a minor proportion of the total MS population, thus having been underrepresented in previous studies. The generalizability of existing evidence may be compromised by differences in symptom expression between MS phenotypes, with a dominance of motor symptoms (i.e., paraspasticity and/or paraparesis) in PPMS and SPMS. Adding up to this, clinical experiences of neurologists and sports scientists reveal that the effects of endurance exercise are characterized by a distinct time course, firstly inducing a minor and transient deterioration of motor symptoms that is followed by motor symptom alleviation beyond baseline level. This phenomenon was mainly related to the performance of High-Intensity Interval training (HIIT), but not to moderate-intensity continuous training (MCT). Therefore, this pilot study aims to systematically investigate the time course of acute motor effects on spasticity, functional mobility, gait, and dexterity in persons with PPMS and SPMS following two different endurance training protocols, that are HIIT and MCT.

NCT ID: NCT02549573 Terminated - Parkinson's Disease Clinical Trials

Outpatient Physical Therapy Intervention in Subjects With Parkinson's Disease Currently Using APOKYN®

PERFORM
Start date: January 2016
Phase: Phase 4
Study type: Interventional

To determine if PT intervention will be improved while in the "on" motor state vs. the "end-of-dose-off" motor state during the PT Intervention Visit in subjects with PD.

NCT ID: NCT01770145 Completed - Parkinson's Disease Clinical Trials

Apokyn for Motor IMProvement of Morning AKinesia Trial (AM IMPAKT)

AM IMPAKT
Start date: December 2012
Phase: Phase 4
Study type: Interventional

This study is designed to assess the effect of APOKYN treatment in rapid and reliable improvement of motor symptoms in Parkinson's disease (PD) subjects suffering from delayed or unreliable onset of levodopa (L-dopa) action.