Motor Neuron Disease Clinical Trial
Official title:
Movement Related Cortical Potentials in Primary Lateral Sclerosis
This study will examine whether the motor cortex (the part of the brain that controls
movement) works properly in patients with primary lateral sclerosis (PLS), a disorder in
which voluntary movements are very slow.
Healthy volunteers between 40 and 75 years of age and patients with ascending PLS (a subset
of PLS) may be eligible for this study. Patients with ascending PLS have a slowing of
finger-tapping movements that corresponds to a particular abnormality of certain neuronal
(nerve cell) activity.
Participants perform a finger-tapping reaction time exercise while brain wave activity
(electroencephalography, or EEG) and muscle activity (electroymogram, or EMG) are measured.
The subject is seated in front of a computer screen. A signal appears on the screen and the
subject taps a key as quickly as possible in response to the signal.
For the EEG, brain activity is recorded by placing electrodes (small metal discs) on the
scalp with an electrode cap or glue-like substance. A conductive gel is used to fill the
space between the electrodes and the scalp to make sure there is good contact between them.
The brain waves are recorded while the subject taps his or her fingers very slowly. For the
surface EMG, electrodes filled with a conductive gel are taped to the skin.
Participants also undergo magnetic resonance imaging (MRI). This test uses a strong magnetic
field and radio waves to obtain images of the brain. During the procedure, the subject lies
still on a table that can slide in and out of the scanner - a narrow metal cylinder.
Scanning time varies from 20 minutes to 3 hours, with most scans lasting between 45 and 90
minutes. Subjects can communicate with the MRI staff at all times during the scan and can
ask to be moved out of the machine at any time.
Status | Completed |
Enrollment | 36 |
Est. completion date | February 2006 |
Est. primary completion date | |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | Both |
Age group | N/A and older |
Eligibility |
INCLUSION CRITERIA: Patients 1. Ages 40-75 2. Fulfill the proposed diagnostic criteria for PLS of Pringle 1992. 3. Have an ascending course of symptom progression. 4. Slow hand movements, as determined by measuring finger-tapping speeds of 20-65 taps in 15 s. 5. Absent motor evoked potentials in hand muscles with 100% output of the MagStim200 transcranial magnetic stimulator. Normal Volunteers Healthy adult volunteers ages 40-75 who are willing to participate. EXCLUSION CRITERIA: 1. Neurological diseases or conditions other than PLS. 2. Implanted devices, such as pumps, pacemakers, or metal fragments in the skull or eye. 3. Pregnancy as determined by urine pregnancy test within 48 hours of MRI study in women of childbearing |
N/A
Country | Name | City | State |
---|---|---|---|
United States | National Institute of Neurological Disorders and Stroke (NINDS) | Bethesda | Maryland |
Lead Sponsor | Collaborator |
---|---|
National Institute of Neurological Disorders and Stroke (NINDS) |
United States,
Rowland LP. Primary lateral sclerosis: disease, syndrome, both or neither? J Neurol Sci. 1999 Nov 15;170(1):1-4. Review. — View Citation
Sasaki S, Iwata M. Ultrastructural study of Betz cells in the primary motor cortex of the human brain. J Anat. 2001 Dec;199(Pt 6):699-708. — View Citation
Swash M, Desai J, Misra VP. What is primary lateral sclerosis? J Neurol Sci. 1999 Nov 15;170(1):5-10. Review. — View Citation
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