Somesthesic Role of the Ventro-lateral Prefrontal Cortex in Speech Motor Learning

Motor Activity Clinical Trial

— BRAVA²  

Official title:

Somesthesic Role of the Ventro-lateral Prefrontal Cortex in Speech Motor Learning fMRI Study

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT04547569
• Other study ID #: 38RC18.173
• Status: Completed
• Phase: N/A
• Start date: October 20, 2020
• Est. completion date: July 6, 2021

Study information

• Verified date: May 2022
• Source: University Hospital, Grenoble
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

These studies test the hypothesis that frontal areas of the brain participate in the cortical networks involved in the somotosensory processing that happens during speech motor learning.

Description:

This work aims to study the role of sensory systems in human motor learning and specifically addresses the involvement of somatosensory cortical networks in motor learning of speech. Previous studies in the literature have highlighted the plasticity of cortical sensory networks, notably the primary and secondary somatosensory cortex and the ventral premotor cortex, during motor learning tasks. The present project focuses on the somatosensory region with connections to the sensorimotor regions of the frontal and parietal cortex. We propose to use neuroimaging (fMRI), in order to verify which areas in the prefrontal cortex are part of the sensorimotor network used in the learning of speech motor tasks in humans. Subjects will be tested in the fMRI scanner while performing either a behavioral task in which the auditory feedback of their own speech is altered or while performing a vibrotactile discrimination task.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 16
• Est. completion date: July 6, 2021
• Est. primary completion date: July 6, 2021
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years to 35 Years

Eligibility

Inclusion Criteria:

• Right-handed subjects
• Subjects fluent in French
• Signed informed consent
• Affiliation to or beneficiary of a Social Security scheme

Exclusion Criteria:

• Left-handed subjects
• Criteria for contraindications to protocol fMRI scans
• Existence of a severe general condition: cardiac, respiratory, hematological, renal, hepatic, cancerous.
• Hearing, language (including dyslexia), neurological or psychiatric disorders.
• Participation in other ongoing intervention research protocols with exclusionary period or within the previous week
• Drug treatment likely to modulate brain activity: benzodiazepines, antidepressants, neuroleptics, lithium, etc.
• Protected persons referred to in articles L1121 5 to L1121 8 of the French CSP:
• Pregnant women, parturients, nursing mothers,
• Persons deprived of liberty by a judicial or administrative decision,
• Persons under psychiatric care,
• Individuals admitted to a health or social institution for purposes other than research,
• Minors,
• Persons over the age of majority who are subject to a legal protection measure or who are unable to express their consent

Related Conditions & MeSH terms

• Motor Activity
• Speech

Intervention

Behavioral:
• Speech adaptation
Sensorimotor adaptation in speech
• Vibrotactile Discrimination
Vibrotactile Discrimination

Other:
• fMRI
fMRI measurement of brain activity

Behavioral:
• Speech production
Speech production task

Locations

Country	Name	City	State
France	CHU Grenoble-Alpes	Grenoble

Sponsors (4)

Lead Sponsor	Collaborator
University Hospital, Grenoble	GIPSA-LAB, Laboratoire de Psychologie et NeuroCognition, McGill University

Country where clinical trial is conducted

France, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Motor Learning	Learning is assessed as percentage change in speech sounds (speech formant frequencies) relative to baseline.	Performance as measured at the end of learning (during the 1h30 scanner session)
Primary	Brain activity	Brain activity are measure by the BOLD signal during both task-based and resting-state blocks	1h30 scanner session