Melatonin Supplementation and Performance

Motor Activity Clinical Trial

— MSP  

Official title:

Nocturnal Melatonin Ingestion Ameliorates Short Term Maximal Performances on the Following Day

Clinical Trial Details — Status: Terminated

Administrative data

• NCT number: NCT02876770
• Other study ID #: CNMSS1
• Status: Terminated
• Phase: Phase 0
• First received: August 2, 2016
• Last updated: August 18, 2016
• Start date: December 2012
• Est. completion date: January 2013

Study information

• Verified date: August 2016
• Source: University of Sfax
• Contact: n/a
• Is FDA regulated: No
• Health authority: Tunisia: Ministry of health
• Study type: Interventional

Clinical Trial Summary

The present study aimed to evaluate the possible effect of nocturnal melatonin ingestion upon short-term performances, on the following morning. Twelve soccer players from a Tunisian squad (22.9 ±1.3 years, 1.80±0.05 m, and 72.0±8.8 kg) were volunteered to perform three testing sessions, with one test session per day. During each session, MEL (5mg) , MEL (8mg) or placebo were ingested, in a randomized order, before nocturnal sleep. The next morning (08:00h), participants performed the following psycho-cognitive and physical tests: Hooper's index, reaction time, vigilance, handgrip strength , squat jump , modified agility test , Wingate anaerobic test (peak power , mean power and fatigue index ). Rating of perceived exertion was recorded immediately after the WanT, and blood lactate measures were taken after 3min of recovery. Blood glucose was measured before and 3 min after the Wingate test.

Recruitment information / eligibility

• Status: Terminated
• Enrollment: 12
• Est. completion date: January 2013
• Est. primary completion date: January 2013
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Male
• Age group: 20 Years to 23 Years

Eligibility

Inclusion Criteria:

The participants were recruited based on the following criteria: (i) paticipants must be trained at 4-6 days per week for an average of 2 h daily and (ii) they must have at least 8 years of training experience

Exclusion Criteria:

• Subjects were excluded from the study if they present one of the following criteria :

heart failure, antioxidant supplementation within 3 months before the study, lower-limb injuries

Study Design

Allocation: Randomized, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Basic Science

Related Conditions & MeSH terms

• Motor Activity

Intervention

Dietary Supplement:
• Experimental: Melatonin
Our protocol was composed of three experimental sessions. During each testing session, participants were requested to attend the laboratory at 20:00h where they ingested a standardized light meal. Melatonin (5 mg or 8 mg) or placebo were ingested in capsule in the evening at 21:00h in a double-blind randomized design
• Placebo
In a double-blind randomized design, participants have taken placebo supplementation in one of the three experimental sessions

Locations

Country	Name	City	State
n/a

Sponsors (1)

Lead Sponsor	Collaborator
kais

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Hooper's index score	Hooper's index score was measured using a specific questionnaire	At 07:30 am in the following day of the supplementation	No
Primary	handgrip strength (in Kg)	handgrip strength was measured using a calibrated hand dynamometer.	At 07:30 am in the following day of the supplementation	No
Primary	Blood lactate (µmol/l)	Lactate level was measured using Lactate Pro instrument.	Blood lactate was measured only 3 minutes after physical testing in the following day of the supplementation	No
Primary	reaction time (in secondes)	Reaction time was measured using an electronic timing device.	At 07:30 am in the following day of the supplementation	No
Primary	vigilance score	Vigilance score was measured using a specific questionnaire	At 07:30 am in the following day of the supplementation	No
Primary	squat jump (in centimeters)	Squat jump was assessed using a infrared jump system	At 07:30 am in the following day of the supplementation	No
Primary	agility (in secondes)	Agility was assessed using an electronic timing system.	At 07:30 am in the following day of the supplementation	No
Primary	anaerobic capacity (In watts)	Anaerobic capacity was assessed using a calibrated friction-loaded cycle ergometer	At 07:30 am in the following day of the supplementation	No
Primary	glucose level (µmol/l)	Glucose level was assessed using a glucometer	At 07:30 am in the following day of the supplementation (rest condition) and 3 minutes after physical testing in each experimental session	No
Primary	Rating of perceived exertion score	Rating of perceived exertion score was measured using a specific questionnaire	Rating of perceived exertion score was measured 3 minutes after physical testing in the following day of the supplementation	No