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Rectal Indomethacin as Early Treatment for Acute Pancreatitis (INDOMAP Trial) — INDOMAP  

Acute Pancreatitis Clinical Trial

Official title:
Rectal Indomethacin as Early Treatment for Acute Pancreatitis (INDOMAP Trial): Study Protocol for a Multi-center, Double-blinded, Placebo-controlled, Randomized Clinical Trial

Clinical Trial Summary

Acute pancreatitis (AP) is an inflammatory condition of the pancreas following the activated pancreatic enzymes induced by varied causes, with or without other organ(s) dysfunction. The production and release of inflammatory factors is generally considered as the key factor of pathogenesis. Non-steroidal anti-inflammatory drugs (NSAIDs) are the most commonly applied agents for inflammatory diseases. A series studies have proved that indomethacin can reduce the risk of post-endoscopic retrograde cholangiopancreatography (ERCP), but high-quality evidence is still lacking in the field of effectiveness of NSAIDs to treat, rather than prevent, other types of AP. Majority of animal experiments showed that NSAIDs had protective effects for organ functions, but the results of several preliminary clinical studies were inconsistent. Randomized controlled trials are eagerly awaited to elucidate its effects on AP.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03547232
Study type Interventional
Source Peking Union Medical College Hospital
Contact Dong Wu, M.D.
Phone 8618612671010
Email dongwu@pumc.edu.cn
Status Recruiting
Phase Phase 4
Start date June 1, 2024
Completion date June 1, 2030
View Details
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