Mood Swings Clinical Trial
Official title:
The Effect of Moderate Alcohol Consumption With a Meal in Different Ambiances on Postprandial Mood, Evaluated by Subjective and Physiological Responses
Rationale: Food choice is influenced by postprandial mood; the feelings of well-being after
a meal. Postprandial mood can be measured by subjective responses. Physiological responses
may play an important role in the generation of postprandial mood. However, the relationship
between subjective and physiological responses after a meal is not clear yet. To investigate
this relationship, moderate alcohol consumption will be used as a mood modulator, because of
its well-studied effects on mood. Postprandial mood depends on the current mood state.
Therefore the investigators will manipulate the current mood state by changing the ambiance
to measure the influence of moderate alcohol consumption with a meal on postprandial mood in
a pleasant or unpleasant ambiance.
Objective: To determine whether moderate alcohol consumption with a meal in different
ambiances affects postprandial mood, evaluated by subjective and physiological parameters.
Study design: Randomized, placebo-controlled, single-blind, cross-over trial
Study population: 28 apparently healthy, normal weight (BMI 18.5-27 kg/m2) women (18-45 y),
taking oral contraceptives.
Intervention: 4 times having dinner at TNO Zeist with either 3 glasses of sparkling white
wine (~30g alcohol) or alcohol-free sparkling white wine in either a pleasant or unpleasant
meal ambiance.
Hypothesis: It is hypothesized that moderate alcohol consumption with a meal in different
ambiances changes the response of subjective and physiological parameters of mood.
- Ho: there is no effect of alcohol consumption and ambiance on mood
- H1: there is an effect of alcohol consumption and ambiance on mood
n/a
Allocation: Randomized, Intervention Model: Crossover Assignment, Masking: Single Blind (Subject), Primary Purpose: Basic Science