Monochorionic Twins Clinical Trial
Official title:
Unequal Placental Sharing in Monochorionic Diamniotic Twins: an Observational Study to Investigate Prediction and Outcome: the TWINSHARE Study
This is an observational study in 3 cohorts of monochorionic diamniotic (MCDA) twins. The aim of the study is to assess whether unequal placental sharing can be predicted in pregnancy and whether it is predictive of pregnancy outcome.
In all cohorts, serial ultrasound will be performed during pregnancy. MRI will be offered
once during pregnancy. After delivery, placental examination will be performed.
In unselected MCDA twins, the investigators will assess the relationship between unequal
placental sharing and the risk of fetal or neonatal loss. The investigators will also
establish whether umbilical vein measurements or MRI can be used to predict placental
sharing.
In cases complicated by twin-to-twin transfusion syndrome (TTTS), the investigators will
look at the association between unequal placental sharing and intrauterine fetal demise
after laser surgery.
In cases complicated by selective intra-uterine growth restriction (sIUGR), the the
relationship between unequal placental sharing and the risk of fetal or neonatal loss and
birth prior to 34 weeks will be assessed.
Furthermore, data on neurological outcome at 2 years of age in all cohorts will be
collected.
;