Molar, Third Clinical Trial
Official title:
Comparative Effectiveness of Preemptive Ibuprofen, Ketamine, and Their Combination in Postoperative Pain and Trismus Management Following Third Molar Surgery
The goal of the clinical trial is to compare the efficacy of ibuprofen, ketamine, and their combination in managing postoperative pain and trismus following third molar surgery. The main question it aims to answer is: which is the best way to control pain and trismus after third molar surgery?
Status | Recruiting |
Enrollment | 100 |
Est. completion date | September 15, 2023 |
Est. primary completion date | September 15, 2023 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 18 Years to 25 Years |
Eligibility | Inclusion Criteria: - Patients with a fully embedded third molar tooth in the mandible - Patients with regular attendance for routine follow up - Patients with a healthy general systemic condition Exclusion Criteria: - Patients with a fully erupted or partially embedded third molar tooth in the mandible - Patients who have previously experienced allergies to NSAIDs, local anesthetics, and ketamine - Pregnant or breastfeeding patients - Patients who have recently used a different group of NSAIDs for a different condition |
Country | Name | City | State |
---|---|---|---|
Turkey | Erciyes University Faculty of Dentistry | Kayseri |
Lead Sponsor | Collaborator |
---|---|
Cihan Topan | TC Erciyes University |
Turkey,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | The pain level measurement after impacted third molar surgery will be assessed with the visual analog scale (VAS) in all groups. | VAS (Pain intensity was assessed on a 100-mm visual analoge scale, where 0=no pain and 100=worst possible pain) | The pain level measurements of all patients will be evaluated by a visual analog scale (VAS) two hours following impacted third molar surgery. [All study participants were asked to record their pain levels two hours after surgery]. | |
Primary | The pain level measurement after impacted third molar surgery will be assessed with the visual analog scale (VAS) in all groups. | VAS (Pain intensity was assessed on a 100-mm visual analoge scale, where 0=no pain and 100=worst possible pain) | The pain level measurements of all patients will be evaluated by a visual analog scale (VAS) six hours following impacted third molar surgery. [All study participants were asked to record their pain levels six hours after surgery]. | |
Primary | The pain level measurement after impacted third molar surgery will be assessed with the visual analog scale (VAS) in all groups. | VAS (Pain intensity was assessed on a 100-mm visual analoge scale, where 0=no pain and 100=worst possible pain) | The pain level measurements of all patients will be evaluated by a visual analog scale (VAS) 12 hours following impacted third molar surgery. [All study participants were asked to record their pain levels 12 hours after surgery]. | |
Primary | The pain level measurement after impacted third molar surgery will be assessed with the visual analog scale (VAS) in all groups. | VAS (Pain intensity was assessed on a 100-mm visual analoge scale, where 0=no pain and 100=worst possible pain) | The pain level measurements of all patients will be evaluated by a visual analog scale (VAS) 24 hours following impacted third molar surgery. [All study participants were asked to record their pain levels 24 hours after surgery]. | |
Primary | The limitation of mouth opening (trismus) after third molar surgery will be measured in all groups. | Trismus was evaluated preoperatively by measuring the distance between the mesial-incisal corners of the upper and lower right central incisors at the maximum opening of the jaws. | The limitation of mouth opening (trismus) after third molar surgery will be measured in all groups. [The maximum mouth opening of all study participants will be measured and recorded before surgery]. | |
Primary | The limitation of mouth opening (trismus) after third molar surgery will be measured in all groups | Trismus was evaluated on the second day postoperatively by measuring the distance between the mesial-incisal corners of the upper and lower right central incisors at the maximum opening of the jaws. | The limitation of mouth opening (trismus) after third molar surgery will be measured in all groups. [The maximum mouth opening of all study participants will be measured and recorded two days after the surgery]. | |
Primary | The limitation of mouth opening (trismus) after third molar surgery will be measured in all groups | Trismus was evaluated on the seventh day postoperatively by measuring the distance between the mesial-incisal corners of the upper and lower right central incisors at the maximum opening of the jaws. | The limitation of mouth opening (trismus) after third molar surgery will be measured in all groups. [The maximum mouth opening of all study participants will be measured and recorded seven days after the surgery]. | |
Secondary | The secondary outcome measure is the amount of rescue analgesia used by all participants after impacted third molar tooth surgery. | All study participants will record the dose of rescue analgesic medicine (Paracetamol 500 mg) at home if they need to take it within 24 hours following surgery. | The mean amount of rescue analgesia used by all participants within the first 24 hours after surgery will be calculated. |
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