Clinical Trials Logo

Clinical Trial Summary

The goal of the clinical trial is to compare the efficacy of ibuprofen, ketamine, and their combination in managing postoperative pain and trismus following third molar surgery. The main question it aims to answer is: which is the best way to control pain and trismus after third molar surgery?


Clinical Trial Description

Materials and methods The study will comprise 100 individuals who requested to have their mandibular third molar tooth extracted at the Erciyes University Faculty of Dentistry. Participants were randomly allocated into four groups, with 25 patients in each group. The first group (Intrafen group): Each patient in this group will be administered intravenous Ibuprofen (400 mg/8 ml i.v. infusion) for pre-emptive analgesic effect 60 minutes before surgical third molar extraction. Before the procedure, patients will be given local anesthesia using a mixture of 2 ml of local anesthetic (Ultracain Ds Fort 2 ml) plus 3 ml of saline solution (Poliflex 0.9% isotonic 100 ml solution). The impacted third molars of the patients will be removed. The second group (Ketamine group): Each patient in this group will be administered intravenous 100 ml saline (Poliflex 0.9% isotonic 100 ml solution) for a placebo effect 60 minutes before surgical third molar extraction. Before the procedure, patients will be given local anesthesia using a mixture of 2 ml of local anesthetic (Ultracain Ds Fort 2 ml) plus 3 ml of saline solution (Poliflex 0.9% isotonic 100 ml solution) plus 0,3 mg/kg of ketamine (Ketalar 500 mg). The impacted third molars of the patients will be removed. The third group (Combined group): Each patient in this group will be administered intravenous Ibuprofen (400 mg/8 ml i.v. infusion) for pre-emptive analgesic effect 60 minutes before surgical third molar extraction. Before the procedure, patients will be given local anesthesia using a mixture of 2 ml of local anesthetic (Ultracain Ds Fort 2 ml) plus 3 ml of saline solution (Poliflex 0.9% isotonic 100 ml solution) plus 0,3 mg/kg of ketamine (Ketalar 500 mg). The impacted third molars of the patients will be removed. The fourth group (Control group): Each patient in this group will be administered intravenous 100 ml saline (Poliflex 0.9% isotonic 100 ml solution) for a placebo effect 60 minutes before surgical third molar extraction. Before the procedure, patients will be given local anesthesia using a mixture of 2 ml of local anesthetic (Ultracain Ds Fort 2 ml) plus 3 ml of saline solution (Poliflex 0.9% isotonic 100 ml solution). The impacted third molars of the patients will be removed. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT05923775
Study type Interventional
Source TC Erciyes University
Contact Cihan Topan, Doctor
Phone 05556456587
Email cihantopan@hotmail.com
Status Recruiting
Phase N/A
Start date March 1, 2023
Completion date September 15, 2023

See also
  Status Clinical Trial Phase
Recruiting NCT05722509 - Evaluation of a New Technique for Periodontal Pocket Reduction in the Extraction of Wisdom Teeth N/A
Completed NCT05992233 - "Effectiveness of Dual-Wavelength Laser Therapy in Third Molar Extraction Pain, Swelling, and Trismus" N/A
Not yet recruiting NCT05924191 - Preventive Effect of Photobiomodulation in the Postoperative Period of Extractions of Retained Lower Third Molars N/A
Withdrawn NCT05374993 - An Early Feasibility Evaluation of a Novel 3rdMolarTooth Bud Ablation Procedure N/A
Completed NCT04182191 - Influence of CYP2C9 Genotype on Clinical Efficacy of Tenoxicam Phase 4
Completed NCT04203771 - Probiotic Intervention After Surgical Removal of Mandibular Third Molars N/A
Not yet recruiting NCT06452134 - Evaluation the Effect of Coenzyme Q10 on Tissue Healing Process in Patients Undergoing Wisdom Tooth Extraction Phase 4
Recruiting NCT05941130 - 3D Evaluation of Postoperative Edema After Third Molar Surgery Phase 4
Completed NCT04033744 - Prevention of Mandibular Third Molar Extraction- Associated Periodontal Defects Using Platelet-Rich Fibrin N/A
Completed NCT00154518 - The Role of Matrix Metalloproteinases (MMPs) in Orthodontic Tooth Movement Phase 1
Active, not recruiting NCT06073535 - The Use of Injectable-Platelet Rich Fibrin (i-PRF) in the Lower Third Molar Extraction N/A
Completed NCT03545022 - Acupuncture on Anxiety and Inflammatory Events Following Surgery of Mandibular Third Molars N/A
Completed NCT02890680 - Effects of the Use of Platelet-rich Fibrin on Bone Regeneration After Impacted Third Molar Surgery N/A
Recruiting NCT02284841 - Effect of Hilotherm Therapy on Post-operative Pain and Swelling Following Surgical Wisdom Tooth Removal N/A
Recruiting NCT01896427 - Comparing Pain and Swelling After Surgical Extraction of Mandibular Third Molar in Dexamethasone Injection and Without Corticosteroid Methods Phase 4
Enrolling by invitation NCT03567369 - 92/5000 Preoperative Efficacy of Traumeel Versus Dexamethasone in the Control of Pain, Swelling and Trismus N/A