Absolute Number, Density of Immune Infiltrate and Dendritic Cells and Inflammatory Cytokines Expression Pattern. Clinical Trial
Official title:
Evaluation of Lymphocytic Infiltrate, Dendritic Cells and Cytokines Expression in Psoriatic Lesion and Normal Skin Before and After Adalimumab Therapy
The efficacy of TNF alfa inhibitors in the treatment of psoriasis has been documented in
many studies.
Their effect on dendritic cells has been scarcely studied. TNF- α has a central role in
dendritic cell biology, both for their maturity and mobilization of peripheral tissues to
secondary lymphoid organs.
The primary objectives of this study are:
- To document absolute number, density of immune infiltrate and dendritic cells and
inflammatory cytokines expression pattern (particularly IFN α and IL-32) in psoriasic
lesions vs normal skin of the same patient
- To describe changes in such cell numbers and expression patterns upon 16 weeks
treatment with TNF alfa inhibitors.
n/a
Endpoint Classification: Pharmacodynamics Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Basic Science