| Eligibility |
Inclusion Criteria:
- Ability to confirm voluntary participation and agree with all the purposes of the
trial, signing and dating the Free and Informed Consent Form (TCLE) and/or the Free
and Informed Assent Form (TALE) in two copies;
- Age equal to or over 15 years old;
- Indication of extraction of two (02) impacted third molars, one (01) lower third molar
and one (01) upper molar on the same side;
- Third molar with bone impactions observed through panoramic radiography, with
classification by Winter (1926) (1) mesioangular or vertical, and classification
according to Pell & Gregory (1933) (2):
i. Class II position B; or ii. Class III position A or B
- Presence of pain of moderate or severe intensity (score greater than or equal to 5
when assessed using an 11-point numeric pain scale) within up to four (04) hours after
the end of the surgery.
Exclusion Criteria:
- Presence of local conditions (lesions in the region of the third molars) that may
interfere with the extraction of third molars, such as, but not limited to,
pericoronitis, periodontitis, tumors, cysts and inflammation and/or infection in the
region to be operated;
- Presence of any clinical observation finding (clinical/physical assessment) or
laboratory condition that is interpreted by the investigating physician as a risk to
the research participant's participation in the clinical trial or the presence of
uncontrolled chronic disease(s);
- Presence of a known gastroduodenal ulcer or diagnosis of persistent gastritis;
- Presence of compromised bone marrow function or diseases of the hematopoietic system;
- Presence of known severe renal and/or hepatic insufficiency;
- Diagnosis of epilepsy not adequately controlled;
- Diagnosis of acute intermittent hepatic porphyria;
- Presence of known congenital glucose-6-phosphatedehydrogenase deficiency;
- History of allergy or intolerance to tramadol, diclofenac and pyrazolones (e.g.
phenazone, propyphenazone) or pyrazolidines (e.g. phenylbutazone, oxyphenbutazone)
including, for example, previous experience of agranulocytosis with one of these
substances;
- Use of sedative, hypnotic or psychotropic medications in the last 24 hours before
surgery;
- Use of anticoagulant medications in the last seven (07) days before surgery;
- Current chronic treatment with opioids or corticosteroids;
- Current treatment with selective cyclooxygenase - 2 (COX2) inhibitors;
- Use of monoamine oxidase inhibitors (MAOIs) such as, but not limited to, phenelzine,
tranylcypromine and isocarboxazid, in the last 14 days prior to the day of surgery;
- Use of any analgesic and/or anti-inflammatory medication in the three (03) days prior
to the day of surgery;
- Known allergy or hypersensitivity to the components of the medicines used during the
clinical trial;
- Surgery to extract third molars lasting more than 60 minutes, considering from the
beginning of the incision until the end of the extraction;
- Technical failure in anesthesia or need to administer more than three tubes of
anesthetic for each molar;
- Presence of temporomandibular joint dysfunction or limited mouth opening;
- Occurrence of a surgical accident resulting from the extraction of impacted third
molars which, in the opinion of the investigator, could interfere with the procedures
or evaluations of the trial, such as, but not limited to, intraoperative hemorrhage,
probable injury to the inferior alveolar nerve, board fracture bone and soft tissue
laceration;
- Current medical history of cancer and/or cancer treatment in the last 5 years;
- History of alcohol and/or illicit drug abuse disorder in the last two (02) years;
- Participants who are pregnant, breastfeeding or planning to become pregnant, or female
participants of childbearing potential who are not using a reliable method of
contraception;
- Participation in clinical trial protocols in the last 12 (twelve) months (CNS
Resolution 251, of August 7, 1997, item III, subitem J), unless the investigator
believes that there may be a direct benefit to the participant.
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