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Moderate Asthma clinical trials

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NCT ID: NCT05757908 Completed - Moderate Asthma Clinical Trials

Study Comparing At-Home Mobile Spirometry to In-Clinic in Moderate Asthma Participants Taking Long-Acting Beta Agonist

LEARN
Start date: April 21, 2023
Phase: N/A
Study type: Interventional

The goal of this interventional study is to compare at-home mobile spirometry to in-clinic spirometry in participants with moderate asthma while taking a long-acting beta agonist (LABA). The main questions it aims to answer are: - Do at-home mobile spirometry and in-clinic spirometry assessments show a similar treatment effect (measured changes in FEV1) with the addition of LABA? - Is at-home mobile spirometry as accurate as in-clinic spirometry in showing treatment effects (changes in FEV1)? Participants will be asked to: - Take standard of care LABA treatment once or twice a day - Complete at-home mobile spirometry testing twice a day - Complete asthma questionnaires twice a day - Complete device use questionnaires - Wear a wrist device (like a watch) to track physical activity and vital signs - Visit the clinic for in-clinic spirometry testing once a week for 8 weeks

NCT ID: NCT05735431 Not yet recruiting - Moderate Asthma Clinical Trials

Non-Inferiority,Combination Formoterol/FluticasonexAlenia®Formoterol/Budesonide for Asthma in Brazil

FORASMA
Start date: June 30, 2025
Phase: Phase 3
Study type: Interventional

Eurofarma Laboratórios S.A. markets a FDC containing formoterol 12 mcg/fluticasone 250 mcg, in a single capsule for inhalation (Lugano®; reference product). The product is indicated for the treatment of asthma in patients aged ≥ 12 years. The company seeks to register a product with lower concentrations of mono-drugs (6 mcg and 125 mcg, respectively) to enable the dosage step up and step down treatment strategies advocated by the Global Initiative for Asthma for the inhaled maintenance treatment of asthma (GINA, 2022 ) with these combinations. This Phase 3 study will be carried out for demonstrating the non-inferiority of the investigational drug (FDC of formoterol 6 mcg/fluticasone 125 mcg) compared to the FDC of formoterol 6 mcg/budesonide 200 mcg (Alenia® - Aché Laboratórios Farmacêuticos S.A.) in the maintenance treatment of asthma, allowing its registration as a new concentration of the drug already registered by the company.

NCT ID: NCT04796844 Recruiting - Asthma Clinical Trials

MANI Real-life Perspective Observatory

MANI
Start date: May 1, 2021
Phase:
Study type: Observational [Patient Registry]

The purpose of this registry aims is to collect a large number of patients with mild and moderate asthma in a real-word conditions for a perspective observation of epidemiological evolution of the disease in relation to the therapeutic interventions available currently and in the near future.

NCT ID: NCT02999711 Completed - Asthma Clinical Trials

Study of Safety, Tolerability, and Pharmacokinetics of Multiple Ascending Doses of REGN3500 in Adults With Moderate Asthma

Start date: February 3, 2017
Phase: Phase 1
Study type: Interventional

Purpose of this study is to assess the safety and tolerability of multiple ascending subcutaneous doses of REGN3500 to moderate asthmatics.

NCT ID: NCT02965807 Recruiting - Moderate Asthma Clinical Trials

Effect of Bronchial Thermoplasty on Moderate Bronchial Asthma in China

Start date: February 2015
Phase: Phase 1/Phase 2
Study type: Interventional

This study aims to investigate the efficacy and safety of Bronchial Thermoplasty on moderate bronchial asthma in China, by observing the improvement of quality of life, the decrease of acute attack and emergence, as well as the incidence of related complications.

NCT ID: NCT00262652 Terminated - Moderate Asthma Clinical Trials

Safety and Efficacy Study of the Use of Sodium Pyruvate Bronchodilation in Asthmatics

Start date: January 2006
Phase: Phase 1/Phase 2
Study type: Interventional

Sodium pyruvate in sodium chloride solution will be delivered by nebulization to the lungs. It is believed that this administration will produce bronchodilation in asthmatics as determined by improvement in FEV1. FEV1 is a measure of lung function, and will be determined after administration of sodium pyruvate. The study is a blinded, so subjects may receive either the sodium pyruvate or a sodium chloride placebo. The primary endpoint will be the improvement of FEV1 after 15 minutes in subjects receiving sodium pyruvate compared to the FEV1 of subjects receiving the sodium chloride placebo.