Mixed Urinary Incontinence Clinical Trial
Official title:
Exploration of the Potential of Urinary Nerve Growth Factor (NGF) as a Biomarker for Diagnosis and Prognosis of Mixed Urinary Incontinence After Midurethral Slings
Female urinary incontinence (UI) can be caused by pure stress UI (SUI), pure urgency UI (UUI)
and mixed SUI and UUI (MUI). Clinically it might not be that easy to separate MUI and SUI.
Patients might perceive urgency when they have an incompetent urethra and a full bladder.
Urinary tract nerve growth factor (NGF)is produced by bladder urothelium and smooth muscle.
Increased levels of NGF have been reported in the bladder tissue and urine of patients with
overactive bladder (OAB).
If the urinary levels of NGF differ among women with pure SUI and MUI, then urinary NGF level
might be a biomarker in the differential diagnosis of MUI in women.
Also, decreased urinary NGF level was reported in OAB patients of whom the symptoms were
improved. So, we might expect that the remnant OAB symptom including urgency incontinence can
be improved, if the urinary NGF levels decrease after midurethral slings for SUI in MUI
patients.
We aimed to explore the value of the urinary NGF as a biomarker for differential diagnosis
and as a prognostic marker for predicting the improvement of OAB symptom after midurethral
slings.
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