Mitral Valve Regurgitation Clinical Trial
Official title:
Mitral Valve Replacement With the MValve Dock and A Percutaneous Transcatheter Heart Valve
This study evaluates the MValve mitral prosthesis in conjunction with a Lotus transcatheter heart valve (THV) for mitral valve replacement in subjects at high risk for conventional mitral valve replacement or repair surgery.
This study is a prospective first in man feasibility study intended to evaluate preliminary
safety and effectiveness of the MValve Mitral Dock with Lotus transcatheter heart valve for
mitral valve replacement in subjects who are at high risk for surgical valve repair or
replacement.
The surgical technique adapts the valve-in-valve approach for mitral replacement in
degenerated mitral prostheses to failing native mitral valves. The MValve Dock is designed
to provide a structural platform within the mitral annulus so that the Lotus THV can be
implanted in a secure fashion in the mitral annulus. The investigational device anchors to
the mitral annulus commissures, sparing the native valve leaflets and sub annular apparatus.
This study is designed to treat subjects with moderate-to-severe MR who are not deemed
candidates for mitral valve surgery.
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Endpoint Classification: Safety Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
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