Mitral Regurgitation Clinical Trial
Official title:
Primary Mitral Regurgitation Reverse Remodeling
This longitudinal cohort study evaluates the relationship of myocardial tissue markers characteristics assessed by cardiac MRI, with clinical measures of symptoms and functions in adults with primary mitral regurgitation. Participants are followed conservatively or may choose to undergo surgical repair at the discretion of their clinical team.
The transition from compensated to decompensated chronic primary mitral regurgitation remains
poorly understood in the clinical setting. Changes at the myocardial tissue level, such as
scar formation and decreased contractility, have been implicated in the end stage,
decompensated phase of this disease entity.
Advances in cardiac MRI (CMR) have enabled non-invasive characterization of the myocardial
tissue components, such as cardiomyocyte volume and extracellular matrix, and tissue
contractility. These measures have been well validated in various cardiac pathologies with
biopsy studies but only at single time points.
In this study, adults with isolated chronic primary regurgitation will be followed
conservatively over at least a year to determine the natural progression of these CMR-derived
markers over time and to investigate the prognostic potential of these markers for clinically
assessed functional capacity and symptoms. These participants may elect to undergo any
valvular intervention at the discretion of their treating clinical team.
Alongside this arm, similar adults with isolated chronic primary regurgitation will be
recruited, who have elected upfront to undergo surgical repair. These patients will be
similarly studied to determine reverse remodeling of these CMR-derived markers over time and
to investigate the prognostic potential of these markers for the same clinical outcomes.
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