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NCT01719211 Clinical Trial

Genetic Basis of Mitral Valve Prolapse

Mitral Valve Prolapse Clinical Trial

— MVP  

Official title:
Genetic Basis of Mitral Valve Prolapse

Clinical Trial Details — Status: Recruiting

Administrative data
NCT number NCT01719211
Other study ID # 1999-p-007948
Secondary ID
Status Recruiting
Phase
First received
Last updated
Start date January 1999
Est. completion date December 2025

Study information
Verified date November 2023
Source Massachusetts General Hospital
Contact Susan Slaugenhaupt, PhD
Phone 6176433217
Email slaugenhaupt@chgr.mgh.harvard.edu
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

The investigators have successfully identified two novel genetic loci for MVP on chromosomes 11 and 13 and are searching for altered genes in these regions. This requires recruiting large families who may have MVP linked to these or other chromosomes; and obtaining DNA samples from 1,000-1,500 individually affected patients to study the relation between DNA markers throughout the genome and MVP. It is our expectation that the results of this study will lead to the discovery of gene(s) responsible for MVP. This will lead to improved understanding of the disease and, in turn, improved ability to treat and prevent progression in genetically susceptible individuals.

Description:

This is a genome-wide association study.

Recruitment information / eligibility
Status Recruiting
Enrollment 1500
Est. completion date December 2025
Est. primary completion date December 2025
Accepts healthy volunteers No
Gender All
Age group 18 Years to 80 Years
Eligibility Inclusion Criteria: - Mitral valve prolapse Exclusion Criteria: - Other mitral valve diseases

Study Design

Related Conditions & MeSH terms

Locations
Country Name City State
United States Mass General Hospital Boston Massachusetts

Sponsors (2)
Lead Sponsor Collaborator
Massachusetts General Hospital Leducq Foundation

Country where clinical trial is conducted

United States, 

Outcome
Type Measure Description Time frame Safety issue
Primary Discovery of the genetic basis of Mitral Valve Prolapse Genome-wide association 5 years
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