Mitral Valve Prolapse Clinical Trial
Official title:
Genetic Polymorphisms in Idiopathic Mitral Valve Prolapse :A French Prospective Study Using a Genome Wide Analysis
This prospective nation-wide (France) study aims to search for susceptibility genes in MVP using a genome wide analysis and comparing results obtained in 1000 patients with MVP and 1000 non-MVP subjects.
Two MVP populations will be defined in that study, either with the classical Barlow
(myxomatous) disease or the fibroelastic degenerescence (thin and redundant leaflets).
MVP adult patients (> 18 year-old) will be included if they present the following 1) or 2)
criteria :
1. 2D-echocardiographic mitral leaflet prolapse on the parasternal long-axis view > 2 mm
AND leaflet thickness > 4 mm or mitral regurgitation > 2 + (using color Doppler)
2. Previous surgery for pure severe mitral regurgitation due to MVP with Barlow disease or
fibroelastic degenerescence (with operative report available)
Patients will be excluded in case of associated heart disease (hypertrophic cardiomyopathy,
rheumatismal disease…) or syndromic disease (Marfan, Ehlers-Danlos…).
Around 30 (cardiology, cardiovascular surgery) french centers will participate to this
study. An e-CRF will be used to collect clinical data. A genetic core lab will collect the
DNA samples. An echocardiographic core lab will collect and read all the echo recordings.
DNA analysis will be compared between the patient group and spouses of the patients used as
controls. In case of inadequacies concerning group size or age, available genotyped cohorts
will be used.
;
Allocation: Non-Randomized, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Screening
Status | Clinical Trial | Phase | |
---|---|---|---|
Not yet recruiting |
NCT02499419 -
Exercise Capacity Evaluation in Patients With Non-rheumatic Mitral Valve Prolapse (MVP)
|
N/A | |
Completed |
NCT02105480 -
Automated Algorithm Based Analysis of Phonocardiograms of Newborns
|
||
Completed |
NCT02512341 -
Automatic Differentiation of Innocent and Pathologic Murmurs in Pediatrics
|
||
Enrolling by invitation |
NCT04067635 -
Primary Mitral Regurgitation Repair
|
||
Recruiting |
NCT06378996 -
Arrhythmic Mitral Valve Prolapse Detection Using Long-term Ambulatory Rhythm Monitoring
|
N/A | |
Terminated |
NCT03285724 -
Safety and Performance Study of the Harpoon Mitral Valve Repair System
|
N/A | |
Recruiting |
NCT03506217 -
Using Pulse Counter Vigileo-Flotrac System in Transapical Off-pump Minimally Invasive Mitral Valve Repair
|
||
Completed |
NCT00665301 -
Cardiac Output Pulmonary Arterial Catheter Compared to FloWave™ 1000
|
N/A | |
Not yet recruiting |
NCT04299334 -
Neochordae Technique in Mitral Valve Repair
|
Phase 1 | |
Completed |
NCT03470155 -
Operative Mitral Valve Reconstruction in Functional mv Insufficiency With Reduced Systolic Ventricle Function
|
||
Recruiting |
NCT06341166 -
Multiparametric SCores for Prediction of Myocardial fIbrosis in Patients With MITral vAlve pRolapse
|
||
Completed |
NCT04231903 -
Myocardial Protection in Minimally Invasive Mitral Valve Surgery
|
||
Not yet recruiting |
NCT03609931 -
Patient Specific Mitral Valve Modeling for Surgical Planning and Training
|
||
Recruiting |
NCT05631730 -
Effect and Safety of Flecainide and Metoprolol Versus Metoprolol Alone to Suppress Ventricular Arrhythmias in Arrhythmic Mitral Valve Prolapse
|
Phase 3 | |
Recruiting |
NCT02552771 -
The Canadian Mitral Research Alliance (CAMRA) Trial CardioLink-2
|
N/A | |
Recruiting |
NCT01719211 -
Genetic Basis of Mitral Valve Prolapse
|
||
Recruiting |
NCT04190602 -
Multicenter Post-Market Observational Registry of the NeoChord Artificial Chordae Delivery System
|
||
Recruiting |
NCT03113552 -
Prognostic Impact of the Location of Mitral Valve Prolapse on the Long-term Results of Mitral Plasty
|
||
Recruiting |
NCT06255457 -
Ventricular Arrhythmias in Patients Undergoing Mitral Valve Surgery
|
||
Completed |
NCT02771275 -
Safety and Early Feasibility Study of the Harpoon Medical Device (EFS)
|
N/A |