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Mitral Valve Insufficiency clinical trials

View clinical trials related to Mitral Valve Insufficiency.

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NCT ID: NCT03870516 Not yet recruiting - Clinical trials for Mitral Regurgitation

Left Chamber Function in Mitral Regurgitation and Predicting Outcome After Replacement and Targeting for Early Surgery

Start date: September 20, 2021
Phase: N/A
Study type: Interventional

The study aims to analyze the role of left ventricular and left atrial functional parameters by speckle tracking echocardiography in predicting outcome after mitral valve replacement and targeting for early intervention compared to guideline parameters.

NCT ID: NCT03609931 Not yet recruiting - Clinical trials for Mitral Regurgitation

Patient Specific Mitral Valve Modeling for Surgical Planning and Training

Start date: July 2018
Phase:
Study type: Observational

Mitral valve disease is a common pathologic problem occurring in approximately 2% of the general population but climbing to 10% in those over the age of 75 in Canada[1]. This project has three primary goals all of which will positively affect cardiac patient care. 1) Create patient specific MV models for complex repairs that will allow surgeons the opportunity to practice the repair. 2) Potentially predict the outcomes following minimally invasive repair techniques such as transcatheter treatments (e.g., MitraClip). 3) Provide a model to train individuals on mitral valve repair techniques.

NCT ID: NCT02719912 Not yet recruiting - Clinical trials for Mitral Valve Regurgitation

Mitral Valve Replacement With MValve Dock and Lotus

DOCK 1
Start date: June 2016
Phase: N/A
Study type: Interventional

This study evaluates the MValve mitral prosthesis in conjunction with a Lotus transcatheter heart valve (THV) for mitral valve replacement in subjects at high risk for conventional mitral valve replacement or repair surgery.

NCT ID: NCT02633423 Not yet recruiting - Clinical trials for Mitral Regurgitation

Expiratory Flow Limitation and Mechanical Ventilation During Cardiopulmonary Bypass in Cardiac Surgery

Start date: January 2, 2018
Phase: N/A
Study type: Interventional

During general anesthesia a reduction of Functional Residual Capacity (FRC) was observed. The reduction of FRC could imply that respiratory system closing capacity (CC) exceeds the FRC and leads to a phenomenon called expiratory flow limitation (EFL). Positive End-Expiratory Pressure (PEEP) test is a validated method to evaluate the presence of EFL during anesthesia. Aim of the study will be to asses if mechanical ventilation during CardioPulmonary Bypass (CPB) in cardiac surgery could reduce the incidence of EFL in the post-CPB period. Primary end-point will be the incidence of EFL, assessed by a PEEP test, performed at different time-points in operating room. Co-primary end-point will be shunt fraction, determined before and after surgery. This will be a single center single-blind parallel group randomized controlled trial. Patients will be randomly assigned to four parallel arms with an allocation ratio 1:1:1:1, to receive one of four mechanical ventilation strategies during CPB. 1. Ventilation with a Positive End-Expiratory Pressure (PEEP) of 5 cmH2O before and after CPB; Continuous Positive Airway Pressure (CPAP) during CPB; 2. Ventilation without PEEP before and after CPB; CPAP during CPB; 3. Ventilation with a PEEP of 5 cmH2O before and after CPB; No use of mechanical ventilation during CPB 4. Ventilation without PEEP before and after CPB; No use of mechanical ventilation during CPB

NCT ID: NCT01431222 Not yet recruiting - Clinical trials for Mitral Regurgitation

Abrogation of Mitral Regurgitation Using the MitraClip System in High-Risk Patients Unsuitable for Surgery

ISAR-CLIP
Start date: September 2011
Phase: Phase 4
Study type: Interventional

The primary objective in this randomized trial is to evaluate the safety and efficacy of a MitraClip treatment in symptomatic patients with severe mitral regurgitation in comparison to the previous default medical treatment - in a study population who is not amenable for the conventional surgical approach as current gold standard.

NCT ID: NCT01242397 Not yet recruiting - Clinical trials for Mitral Regurgitation

Mitral Insufficiency Reduction With Biventricular Pacing

MiRBi
Start date: January 2011
Phase: Phase 1
Study type: Interventional

The purpose of this study is to show that CRT(Cardiac Resynchronization Therapy) pacing in patients with severe functional MR (Mitral Regurgitation) who are not currently indicated for CRT will demonstrate chronic benefit of MR reduction( via echo measured MR/LA area and ERO per American Society of ECHO guidelines) and to show that CRT pacing is safe in these patients.