Pathogenesis & Mechanisms of Mitral Annular Calcification

Clinical Trial Description

The aim is to test the hypothesis that Endothelial Progenitor Cells osteoblastic phenotype (EPC-OCNs) play a significant role in the process of Mitral Annular Calcification (MAC) as prognostic markers of calcific cardiac valves. ;

Study Design

See also
Status	Clinical Trial	Phase
Active, not recruiting	`NCT03539458` - Feasibility Study of the Tendyne Mitral Valve System in Mitral Annular Calcification	N/A
Completed	`NCT04093973` - Bicycle Exercise Echocardiography to Assess Physiological Significance of Mitral Annular Calcification
Terminated	`NCT01442467` - Study of Echocardiogram Accuracy in Patients With Mitral Valve Calcification	N/A

See also

Status

Clinical Trial

Phase

Active, not recruiting

NCT03539458 - Feasibility Study of the Tendyne Mitral Valve System in Mitral Annular Calcification

N/A

Completed

NCT04093973 - Bicycle Exercise Echocardiography to Assess Physiological Significance of Mitral Annular Calcification

Terminated

NCT01442467 - Study of Echocardiogram Accuracy in Patients With Mitral Valve Calcification

N/A

Interventional studies are often prospective and are specifically tailored to evaluate direct impacts of treatment or preventive measures on disease.

Observational studies are often retrospective and are used to assess potential causation in exposure-outcome relationships and therefore influence preventive methods.

Expanded access is a means by which manufacturers make investigational new drugs available, under certain circumstances, to treat a patient(s) with a serious disease or condition who cannot participate in a controlled clinical trial.

Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.

Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.

NCT number	NCT04286009
Study type	Observational
Source	Mayo Clinic
Contact
Status	Enrolling by invitation
Phase
Start date	July 28, 2020
Completion date	June 2024

Pathogenesis and Mechanisms of Mitral Annular Calcification

Clinical Trial Summary

Clinical Trial Description

Study Design

Related Conditions & MeSH terms