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Letrozole Pretreatment With Misoprostol fInduction of Abortion In First-Trimester Missed Miscarriage

Miscarriage Clinical Trial

Official title:
Letrozole Pretreatment With Misoprostol for Induction of Abortion In First-Trimester Missed Miscarriage: A Randomized Controlled Trial

Clinical Trial Summary

This study compares the success rate of letrozole and misoprostol versus misoprostol alone for medical termination of first trimester pregnancy.

Clinical Trial Description

According to the American college of obstetricians and gynecologists (2005), medical abortion is an acceptable alternative for surgical procedures in pregnant women with gestational age of less than 49 days based on the last menstrual period

Oral or vaginal misoprostol causes complete abortion in almost 85% of cases within seven days before the 12th week

letrozole administration with misoprostol raises the rate of complete abortion

Hypothesis:

In women with missed miscarriage in the first trimester undergoing induction of abortion pre-treatment with letrozole before misoprostol may lead to abortion rate similar to misoprostol alone. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03628625
Study type Interventional
Source Ain Shams Maternity Hospital
Contact Dina Mansour
Phone +20100657
Email Dinayahiamansour@hotmail.com
Status Recruiting
Phase Phase 2
Start date September 10, 2018
Completion date December 10, 2018
View Details
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