Miscarriage, Recurrent Clinical Trial
Official title:
Effects of Co-treatment With Aromatase Inhibitor or Progestin on Endometrial abv3-integrin Expressions in Women With Recurrent Implantation Failure
Verified date | June 2022 |
Source | Universiti Kebangsaan Malaysia Medical Centre |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
To compare the abv3-integrin expression in endometrium tissue among RIF women between the GnRH analogue with Aromatase Inhibitor (Group A) , GnRH analogue with progesterone (Group B) and GnRH analogue alone as control group (Group C)
Status | Completed |
Enrollment | 39 |
Est. completion date | May 30, 2022 |
Est. primary completion date | December 30, 2021 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | Female |
Age group | 18 Years to 40 Years |
Eligibility | Inclusion Criteria: - Women of 18 to 40 years of age - No significant pre-existing major medical. - Diagnosed as recurrent implantation failure - at least two or more failure of achieving pregnancy following embryo transfer (ET) despite the optimum endometrial thickness and good quality of embryo (unexplained). - Regular menstrual cycle atleast 3 months prior to treatment - Not taking any hormonal treatment for atlest 3months prior to recruitment - Agreed to participate Exclusion Criteria: - Concurrent significant pre-existing major medical conditions such as uncontrolled diabetes, active systemic lupus erythematosus (SLE) or Anti Phospholipid Syndrome (APS) that will interfere with implantation. - Poor quality of embryo - Suboptimal endometrial thickness(<8mm) during the embryo transfer (ET). - On hormonal therapy prior to recruitment. - Not agreed to participate |
Country | Name | City | State |
---|---|---|---|
Malaysia | UniversitiKMMC | Kuala Lumpur |
Lead Sponsor | Collaborator |
---|---|
Universiti Kebangsaan Malaysia Medical Centre |
Malaysia,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | endometrial abv3-integrin expression expressions | pre and post treatment endometrial abv3-integrin expressions | 12 months |
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