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Miscarriage in First Trimester clinical trials

View clinical trials related to Miscarriage in First Trimester.

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NCT ID: NCT06452719 Not yet recruiting - Miscarriage Clinical Trials

Letrozole and Misoprostol for Early Pregnancy Loss Management: A Prospective Pilot Cohort Study

LeMi
Start date: July 15, 2024
Phase: Phase 2
Study type: Interventional

A pilot cohort study to preliminarily investigate the efficacy of pretreatment with letrozole 10 mg daily for three consecutive days followed by treatment with misoprostol 800 mcg vaginally for medical management of early pregnancy loss in a US population. Patients will be followed to assess efficacy of this treatment regimen, as well as additional interventions needed, side effects, adverse events, and patient acceptability.

NCT ID: NCT06384144 Recruiting - Clinical trials for Miscarriage in First Trimester

Machine Learning Miscarriage Management Clinical Decision Support Tool Study

MLMM
Start date: January 1, 2023
Phase:
Study type: Observational

Machine learning used to develop an algorithm to determine chance of success with expectant or medical management for an individual patient. Taking into account the following objective measures: - Demographics: Maternal Age, Parity - History: Previous CS, Previous SMM/MVA, Previous Myomectomy - Gestation by LMP - Presenting symptoms: Bleeding score, Pain score - USS Measurements: CRL, GS, RPOC 3 dimensions, Vascularity - Discrepancy between gestation by CRL and LMP Audit to collate 1000 cases and identify features contributing to an algorithm that can predict outcome of miscarriage management for individualized case management.

NCT ID: NCT06262373 Completed - Clinical trials for Miscarriage in First Trimester

Angular Pregnancy - Ultrasound Definition and Correlation With Clinical Outcomes

Start date: October 1, 2017
Phase:
Study type: Observational

The aim of this study is to establish clinically meaningful ultrasound-based diagnostic criteria for AP. To this end, the investigators will prospectively collect clinical and ultrasound data from early intrauterine pregnancies and correlate this data with pregnancy outcomes (particularly with risk of miscarriage), to establish whether there are any diagnostic criteria that can be used to make the diagnosis, facilitate increased surveillance of at risk pregnancies and reassure those with normally located pregnancies. The collected data will be used to correlate incidence of angular pregnancy and clinical variables such as maternal age, uterine fibroids, assisted conception, multiple pregnancy, ethnicity, previous uterine and adnexal surgery.

NCT ID: NCT05516810 Active, not recruiting - Missed Abortion Clinical Trials

The Accuracy of Ultrasound Diagnosis of Hydatidiform Moles

Start date: October 19, 2021
Phase:
Study type: Observational

This is a prospective observational study assessing which ultrasound findings are best at excluding a molar pregnancy in first trimester miscarriage.

NCT ID: NCT02957305 Completed - Clinical trials for Miscarriage in First Trimester

Misoprostol 400 µg Versus 200 µg for Cervical Ripening in 1st Trimester Miscarriage

MISO200
Start date: December 21, 2016
Phase: Phase 4
Study type: Interventional

Local current protocol for cervical ripening in 1st trimester miscarriage recommends 400 µg of misoprostol intravaginally 3 hours before uterine evacuation. This regime has been recommended by some international guidelines . So far, there are no recent studies comparing cervical dilatation between 400 µg of misoprostol and a reduced dose (e.g., 200 µg) for 6 hours. If cervical ripening is similar between these two regimens(i.e., 200µg regimen is not inferior to 400µg regimen), costs reductions and lower side effects may be issued without losing quality of cervix dilatation.