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Minimally Conscious State clinical trials

View clinical trials related to Minimally Conscious State.

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NCT ID: NCT03494218 Completed - Clinical trials for Minimally Conscious State

Reliability and Validity of the NCS (NCS-R)-Chinese Version

Start date: October 28, 2017
Phase: N/A
Study type: Interventional

The aim of this study was to translate the NCS from English into Chinese and determine the validity of this Chinese version.

NCT ID: NCT03492294 Completed - Clinical trials for Minimally Conscious State

The Role of Music Stimulation in Disorders of Consciousness State: an fMRI Study

Start date: December 2008
Phase:
Study type: Observational

The aim of the present study was to evaluated the neural effect of music on the cerebral activation in unresponsive wakefulness syndrome (UWS) and minimally conscious state (MCS) by using functional magnetic resonance imaging (fMRI).

NCT ID: NCT03389113 Recruiting - Brain Injuries Clinical Trials

Effects of Whole-body Vibration Exercise in Brain Injury Patients With Minimally Conscious State

Start date: January 2, 2017
Phase: N/A
Study type: Interventional

The purpose of this study is to investigate the effect of the whole body vibration exercise on cortical activity and consciousness Level in brain injury patients with minimally conscious state.

NCT ID: NCT03367078 Terminated - Clinical trials for Cognitive Impairment

tDCS in Patients With Disorder of Consciousness Due to Severe Acquired Brain Injury

Start date: June 18, 2018
Phase:
Study type: Observational

The present observational study is aimed at reporting the short-, mid- and long-term outcomes of patients with Disorder of Consciousness (DOC), in Vegetative State (VS) or Minimally Conscious State (MCS), due to a severe Acquired Brain Injury (sABI), after repeated treatments with anodal Transcranial Direct Current Stimulation (tDCS) on Left Dorsolateral Prefrontal Cortex (L-DLPFC), to stimulate recovery of consciousness. The results obtained will also be compared with those of a historical control cohort, before the introduction of tDCS, matched for demographic and clinical characteristics.

NCT ID: NCT03126929 Completed - Clinical trials for Minimally Conscious State

Further Psychometric Data for the Reliability and the Diagnostic Validity of CRS-R

Start date: March 2012
Phase: N/A
Study type: Observational

This study aims to provide, in a large sample, further psychometric data as regards the internal consistency, the test-retest reliability and the diagnostic validity of the Coma Recovery Scale-Revised (CRS-R).

NCT ID: NCT03007784 Recruiting - Clinical trials for Cognitive Impairment

Two Intensities of Transcranial Direct Current Stimulation to Improve Consciousness in Severely Brain Injured Patients

STIMCOM
Start date: January 2017
Phase: Phase 3
Study type: Interventional

Limited treatments are available to improve consciousness in severely brain injured patients. Transcranial Direct Current stimulation (tDCS) is one of the few therapeutics that showed evidence of efficacy to increase level of consciousness and functional communication in some minimally conscious state (MCS) patients, and in some vegetative state (VS) patients. However the optimal intensity of electrical current stimulation remains unknown. This study will test the effects of two intensities of tDCS stimulation (either 0.2mA or 2mA) applied on left dorso-lateral prefrontal cortex on both behavior, - assessed by the Coma Recovery Scale-Revised (CRS-R) scores -, as well as quantified EEG recorded during resting state (using algorithms previously designed and published by the investigators) and event-related potentials (using auditory paradigms we previously published) in severely brain damaged patients with disorders of consciousness (MCS, VS, and conscious but cognitively disabled patients) of various etiologies.

NCT ID: NCT02878837 Completed - Clinical trials for Minimally Conscious State

Dexmedetomidine vs Midazolam for Intraoperative Sedation

Start date: January 2016
Phase: Phase 4
Study type: Interventional

This randomized, open clinical trial sought to compare the use of Midazolam and Dexmedetomidine during surgery in patients under regional anesthesia. The primary objective was to determine the superiority of either drug during the intraoperative period regarding: 1- Depth of sedation and 2- incidence of complications. Secondary objectives included the determination of superiority regarding the postoperative period. For that, patients were randomized into two groups and sedated with either Midazolam or Dexmedetomidine.

NCT ID: NCT02626403 Completed - Clinical trials for Minimally Conscious State

Fronto-parietal tDCS in Severely Brain Injured Patients With Disorders of Consciousness

Start date: January 2015
Phase: N/A
Study type: Interventional

Previous studies showed that anodal transcranial direct current stimulation (tDCS) transiently improves performance of memory and attention. In severely brain injured patients with disorders of consciousness (DOC), a single stimulation over the left dorsolateral prefrontal cortex has shown to improve patients' sign of consciousness. Nevertheless, other brain areas could be stimulated in order to increase the number of responders. In this study, investigators will assess the effects of bilateral fronto-parietal tDCS on Coma Recovery Scale-Revised (CRS-R) scores in patients with DOC in a double-blind sham-controlled experimental design.

NCT ID: NCT02591069 Recruiting - Clinical trials for Minimally Conscious State

Vagal Nerve Stimulation in Coma Patients

SNV
Start date: October 2015
Phase: N/A
Study type: Interventional

Minimally Conscious (MCS) or Vegetative State (VS) are disorders of consciousness which often occur following traumatic brain injury or ischemia. These alterations result most of the time in patients' loss of autonomy and require long years of special care. No efficient therapy to improve patients' consciousness has been found so far. Investigators propose to use vagal nerve stimulation (VNS) to restore cortical activity and patients' embodied self. The investigators' main hypothesis is that VNS will reestablish the thalamo-cortical connectivity leading to an improvement of the consciousness state. To test this hypothesis, investigators will use behavioral measures as well as fMRI, PET scan and EEG to assess brain activity. Patients will be evaluated before and during eight months following implantation of the stimulation device.

NCT ID: NCT02566720 Not yet recruiting - Clinical trials for Traumatic Brain Injury

Amantadine and Functional Improvement Following ABI Measured by MRI Tractography; A Pilot Study

Start date: January 2016
Phase: N/A
Study type: Interventional

This is a pilot study. The objective is to further understand the mechanism by which amantadine improves function in patients with persistent vegetative state and minimally conscious state. Specifically, the investigators will measure the size of the nerve fibers that mediate arousal (reticular activating system, or RAS) pre and post treatment on MRI tractography. MRI findings will be correlated with the Disability Rating Scale (DRS) score. The information gathered from this study will be used to formulate a larger clinical trial.