Mild Dehydration Clinical Trial
Official title:
Sympathetic Reactivity to Water Restriction in Young and Older Adults
| Verified date | January 2021 |
| Source | University of Delaware |
| Contact | n/a |
| Is FDA regulated | No |
| Health authority | |
| Study type | Interventional |
The goal of this project is determine how acute mild dehydration impacts blood pressure control at rest and during static exercise. This protocol will test healthy young and older adults in a normally hydrated and dehydrated condition.
| Status | Completed |
| Enrollment | 35 |
| Est. completion date | June 13, 2019 |
| Est. primary completion date | June 13, 2019 |
| Accepts healthy volunteers | Accepts Healthy Volunteers |
| Gender | All |
| Age group | 20 Years to 75 Years |
| Eligibility | Inclusion Criteria (Young): • age: 20-35 years old Exclusion Criteria (Young): - high blood pressure (>140/90 mmHg) - history of cardiovascular disease - history of cancer - history of diabetes - history of kidney disease - obesity (BMI > 30 kg/m2) - smoking or tobacco use - current pregnancy - nursing mothers - communication barriers Inclusion Criteria (Older): - age: 60-75 years old - ECG within normal limits - screening blood panel within normal limits Exclusion Criteria (Older): - high blood pressure (>140/90 mmHg) - history of cardiovascular disease - history of cancer - history of diabetes - history of kidney disease - obesity (BMI > 30 kg/m2) - smoking or tobacco use - current pregnancy - nursing mothers - communication barriers |
| Country | Name | City | State |
|---|---|---|---|
| United States | William B Farquhar | Newark | Delaware |
| Lead Sponsor | Collaborator |
|---|---|
| University of Delaware | National Heart, Lung, and Blood Institute (NHLBI), National Institute of General Medical Sciences (NIGMS) |
United States,
Robinson AT, Babcock MC, Watso JC, Brian MS, Migdal KU, Wenner MM, Farquhar WB. Relation between resting sympathetic outflow and vasoconstrictor responses to sympathetic nerve bursts: sex differences in healthy young adults. Am J Physiol Regul Integr Comp — View Citation
Watso JC, Babcock MC, Robinson AT, Migdal KU, Wenner MM, Stocker SD, Farquhar WB. Water deprivation does not augment sympathetic or pressor responses to sciatic afferent nerve stimulation in rats or to static exercise in humans. J Appl Physiol (1985). 201 — View Citation
Watso JC, Robinson AT, Babcock MC, Migdal KU, Wenner MM, Stocker SD, Farquhar WB. Short-term water deprivation does not increase blood pressure variability or impair neurovascular function in healthy young adults. Am J Physiol Regul Integr Comp Physiol. 2 — View Citation
| Type | Measure | Description | Time frame | Safety issue |
|---|---|---|---|---|
| Primary | Blood Pressure Variability | Blood pressure variability (BPV) was calculated using standard deviation and using the average real variability index of blood pressure values. The average real variability index calculates the average of absolute differences between consecutive BP measurements and is thought to provide further prognostic value compared with traditional measures of BPV. | During experimental visits 1 and 2 | |
| Primary | Blood Pressure Reactivity - Handgrip Exercise | Change in systolic blood pressure during the second-minute handgrip exercise minus compared to pre-exercise baseline (i.e., at rest). | During experimental visits 1 and 2 |