Cognitive Intervention With Go and Chess in Early and Subjective Cognitive Decline

Mild Cognitive Impairment Clinical Trial

— Cognichess  

Official title:

Cognitive Intervention With Go and Chess in Early and Subjective Cognitive Decline

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT06281652
• Other study ID #: Cognichess
• Status: Recruiting
• Phase: N/A
• Start date: February 13, 2024
• Est. completion date: February 13, 2025

Study information

• Verified date: February 2024
• Source: University of Milano Bicocca
• Contact: Lucio Tremolizzo, MD, PhD
• Phone: +390392339082
• Email: lucio.tremolizzo[@]unimib.it
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The goal of this clinical trial]is to evaluate if learning to play traditional board games could improve cognition in subjects with mild cognitive impairment and subjective cognitive decline. The main questions it aims to answer are: - Do Go and Chess improve cognition? - Is a game better than the other? Is the effect of both games on cognition synergistic? - Do Go and Chess improve quality of life? - Do Go and Chess improve mood? - Do Go and Chess improve lifestyle? Participants will be randomized to one of four groups: - Group intervention with Go, once a week, for 12 weeks - Group intervention with Chess, once a week, for 12 weeks - Group intervention with Go and Chess, twice a week, for 12 weeks - Control group

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 80
• Est. completion date: February 13, 2025
• Est. primary completion date: February 13, 2025
• Accepts healthy volunteers: No
• Gender: All
• Age group: 55 Years and older

Eligibility

Inclusion Criteria:

• Diagnosis of mild cognitive impairment or subjective cognitive decline
• Willingness to participate in the board games classes
• Living within 20-minute driving distance from the center
• Signed informed consent

Exclusion Criteria:

• Prior knowledge of the the game rules (in case the subject knows one of the two, they can be randomized to the other one)
• Significant linguistic or sensory impairment (according to clinical judgment)
• Significant behavioral or psychiatric disturbances (according to clinical judgment)
• Significant medical comorbidities (according to clinical judgment)

Related Conditions & MeSH terms

• Cognitive Dysfunction
• Mild Cognitive Impairment
• Subjective Cognitive Decline

Intervention

Other:
• Go classes
Classes of board games (Go), performed in groups of 6-10 subjects, once a week
• Chess classes
Classes of board games (Chess), performed in groups of 6-10 subjects, once a week

Locations

Country	Name	City	State
Italy	Fondazione IRCCS San Gerardo dei Tintori	Monza	Lombardia

Sponsors (1)

Lead Sponsor	Collaborator
University of Milano Bicocca

Country where clinical trial is conducted

Italy, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	General cognition	Differences in Montreal Cognitive Assessment between groups [continuous scale, 0-30, higher scores indicate better performances]	12 weeks
Secondary	Digit Span Forward	Differences in Digit Span Forward between groups [continuous scale, 0-9, higher scores indicate better performances]	12 weeks
Secondary	Digit Span Backwards	Differences in Digit Span Backwards between groups [continuous scale, 0-9, higher scores indicate better performances]	12 weeks
Secondary	Trail Making Test - part A	Differences in Trail Making Test - part A between groups [time to complete the task, min 0 seconds, max N/A, higher scores indicate worse performances]	12 weeks
Secondary	Trail Making Test - part B	Differences in Trail Making Test - part B between groups [time to complete the task, min 0 seconds, max N/A, higher scores indicate worse performances]	12 weeks
Secondary	Semantic fluency	Differences in Semantic fluency between groups [continuous scale, min 0, max N/A, higher scores indicate better performances]	12 weeks
Secondary	Quality of life indicator	Differences in WHO Quality of life (WHO-QoL) scale between groups [continuous scale, min 0 max 100, higher scores indicate better quality of life]	12 weeks
Secondary	Depression	Differences in geriatric depression scale scale between groups [continuous scale, min 0 max 15, higher scores indicate worse depression]	12 weeks
Secondary	Lifestyle	Differences in simple lifestyle indicator questionnaire scale between groups [continuous scale, min 0 max 10, higher scores indicate healthier lifestyle]	12 weeks